| 3-氨基-二氢噻吩-2-酮类Schiff碱的合成和生物活性研究 |
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| 引用本文： | 孙晓红,李淑娟,刘源发,陈邦,贾婴琦,陶燕.3-氨基-二氢噻吩-2-酮类Schiff碱的合成和生物活性研究[J].有机化学,2007,27(1):82-86. |
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| 作者姓名： | 孙晓红 李淑娟 刘源发 陈邦 贾婴琦 陶燕 |
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| 作者单位： | 1. 西北大学化学研究所,西安,710069
2. 西北大学化学系,西安,710069 |
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| 基金项目： | 陕西省自然科学基金，西北大学校科研和教改项目 |
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| 摘 要： | 通过3-氨基-二氢噻吩-2-酮(DL-高半胱氨酸硫内酯)盐酸盐与取代苯甲醛反应, 得到3-氨基-二氢噻吩-2-酮类Schiff碱. 合成了9个化合物, 其中7个为首次报道的新Schiff碱类化合物. 化合物结构经IR, 1H NMR和元素分析证实, 并对这些化合物进行了室内毒力测试, 结果表明此类化合物具有很好的杀菌、抑菌活性.
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| 关 键 词： | 3-氨基-二氢噻吩-2-酮 Schiff碱 合成 生物活性 |
| 收稿时间： | 2006-3-4 |
| 修稿时间： | 2006-03-10 |
Study on the Synthesis and Biological Activity of Schiff Bases of 3-Amino-dihydrothiophene-2-one |
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| SUN,Xiao-Hong,LI,Shu-Juan,LIU,Yuan-Fa,CHEN,Bang,JIA,Ying-Qi,TAO,Yan.Study on the Synthesis and Biological Activity of Schiff Bases of 3-Amino-dihydrothiophene-2-one[J].Chinese Journal of Organic Chemistry,2007,27(1):82-86. |
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| Authors: | SUN Xiao-Hong LI Shu-Juan LIU Yuan-Fa CHEN Bang JIA Ying-Qi TAO Yan |
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| Institution: | ( Chemical Institute, Northwest University, Xi′an 710069)( Department of Chemistry, Northwest University, Xi′an 710069) |
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| Abstract: | Nine Schiff bases of 3-amino-dihydrothiophene-2-one were synthesized by reaction of substi-tuted benzaldehyde with DL-homocysteine thiolactone hydrochloride by means of preferable reaction condi-tions. Seven of them were reported for the first time. The structures of the compounds were confirmed by elemental analysis, 1H NMR and IR spectra. The biological tests showed that they were excellent biological active to several vegetable pathogen. |
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| Keywords: | 3-amino-dihydrothiophene-2-one Schiff base synthesis biological activity |
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