| 5-[5-(3-吡啶)-2H-四唑亚甲基]-2-芳酰氨基-1,3,4-噻二唑的合成 |
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| 引用本文： | 张自义,杨丰科.5-[5-(3-吡啶)-2H-四唑亚甲基]-2-芳酰氨基-1,3,4-噻二唑的合成[J].有机化学,1994(5). |
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| 作者姓名： | 张自义 杨丰科 |
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| 作者单位： | 兰州大学化学系，兰州大学应用有机化学国家重点实验室 甘肃，兰州，730000，甘肃，兰州，730000 青岛化工学院 |
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| 摘 要： | 正如前文报道,l,3,4—噻二唑类杂环之所以有除草,植物生长调节,驱虫以及消炎等多种生物活性,无疑起因于噻唑母核。尽管母核上取代基不起主导作用,但它作为辅助基,在改善分子溶解性以及药效方面所产生的影响是不能忽略的。因而深入研究各种生物活性基团导入噻二唑环母核以制得多结构单元聚集于同一分子中的噻二唑新衍生物,对于开发多功能新药具有一定的理论意义和实际价值。
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| 关 键 词： | 1 3 4-噻二唑 杂环化合物 酰氨基硫脲 |
Syntheses of 5-[5-(3-pyridinyl)-2H-tetrazolylmethylene] -2-aroylamino-1, 3, 4-thiadiazoles |
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| ZHANG Zi-Yi,YANG Feng-Ke.Syntheses of 5-[5-(3-pyridinyl)-2H-tetrazolylmethylene] -2-aroylamino-1, 3, 4-thiadiazoles[J].Chinese Journal of Organic Chemistry,1994(5). |
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| Authors: | ZHANG Zi-Yi YANG Feng-Ke |
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| Abstract: | A series of new 5-5-(3-pyridinyl)-2H-tetrazolylmethylene] -2-aroylamino-1,3,4 -thiadiazoles 2a- j were obtained by refluxing l- 5-(3-pyridinyl)-2H-tetrazolylacetyl] -4-aroylthiosemicabazides la- j in glacial acetic acid. The compounds la- j were prepared by the reaction of 5-(3-pyridinyl)-2H-tetrazolylacetic hydrazide with aroyl isothiocy-anates. It is suggested that compounds 1a-b representatives are degraded first and followed by a cyclization in the presence of alkaline medium. |
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| Keywords: | 1 3 4-thiadiaole heterocyclic acylthiosemicarbazides |
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