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| 麦斛细胞毒活性成分研究 | |
| 引用本文： | 谭桂山,孙丽,曹建国,王秀梅,李福双,徐康平,邓银华,颜冬兰,章为,周应军,李元建.麦斛细胞毒活性成分研究[J].有机化学,2006,26(3):372-374. |
| 作者姓名： | 谭桂山 孙丽 曹建国 王秀梅 李福双 徐康平 邓银华 颜冬兰 章为 周应军 李元建 |
| 作者单位： | 1. 中南大学湘雅医院,长沙,410008;中南大学药学院,长沙,410013 2. 南华大学肿瘤研究所,衡阳,421001 3. 中南大学药学院,长沙,410013 |
| 基金项目： | 致谢感谢湖南师范大学刘林翰教授鉴定原植物,湖南大学生物传感与化学计量学国家重点实验室代测^1H NMR,^13C NMR和MS图谱,中国军事医学科学院代测HRMS图谱. |
| 摘 要： | 利用硅胶、聚酰胺柱层析等分离方法, 从麦斛全草的乙醚萃取物中分离得到4个化合物, 经化学方法和光谱分析(UV, IR, NMR, MS)鉴定为3,4,7-三羟基-2-甲氧基菲(1), 2,5-二羟基-4-甲氧基菲(2), eugenitin (3)和2,5-二羟基-4-甲氧基-9,10-二氢菲(4), 其中1为新化合物. 采用MTT法分别测得化合物1和2对体外培养的人急性髓性白血病细胞和人肝癌细胞增殖的抑制活性, 并分别考察了增敏剂葛根素对化合物1和2增殖活性的协同作用. |
| 关 键 词： | 麦斛 3 4 7-三羟基-2-甲氧基菲 人急性髓性白血病细胞 人肝癌细胞 葛根素 |
| 收稿时间： | 04 4 2005 12:00AM |
| 修稿时间： | 09 12 2005 12:00AM |
Cytotoxic Constituents from Bulbuphyllum inconsipicum |
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| TAN,Gui-Shan,SUN,Li,CAO,Jian-Guo,WANG,Xiu-Mei,LI,Fu-Shuang,XU,Kang-Ping,DENG,Yin-Hua,YAN,Dong-Lan,ZHANG,Wei,ZHOU,Ying-Jun,LI,Yuan-Jian.Cytotoxic Constituents from Bulbuphyllum inconsipicum[J].Chinese Journal of Organic Chemistry,2006,26(3):372-374. | |
| Authors: | TAN Gui-Shan SUN Li CAO Jian-Guo WANG Xiu-Mei LI Fu-Shuang XU Kang-Ping DENG Yin-Hua YAN Dong-Lan ZHANG Wei ZHOU Ying-Jun LI Yuan-Jian |
| Institution: | a Xiangya Hospital Affiliated to Central South University, Changsha 410008; b School of Pharmaceutical Sciences, Central South University, Changsha 410013;c Cancer Research Institute, Nanhua University, Hengyang 421001 |
| Abstract: | A novel compound, 2-methoxy-3,4,7-trihydroxy-phenanthrene (1), along with 4-methoxy- 2,5-dihydroxy-phenathrene (2), eugenitin (3) and 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (4), was isolated from Bulbuphyllum inconsipicum. 1 and 2 suppressing HL-60 and SMMC-7721 cells were investigated in vitro with cytotoxic activity. Furthermore, synergistic inhibition of 1 and 2 with puerarin was assessed. |
| Keywords: | Bulbuphyllum inconsipicum 2-methoxy-3 4 7-trihydroxy-phenanthrene cytotoxic activity puerarin |
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