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双(二苄基锡杂环羧酸酯)氧化物的合成与表征
引用本文:尹汉东,王传华,王勇,马春林.双(二苄基锡杂环羧酸酯)氧化物的合成与表征[J].有机化学,2000,20(3):415-418.
作者姓名:尹汉东  王传华  王勇  马春林
作者单位:聊城师范学院化学系,聊城,252059
基金项目:山东省自然科学基金(Q98B01117)及山东大学晶体材料国家重点实验室资助课题。
摘    要:通过二苄基氧化锡与杂环取代羧酸反应,合成了8种新的双(二苄基锡杂环羧酸酯)氧化物{(PhCH~2)~2SnO~2CR]~2O}~2(R=2-呋喃基,2-呋喃乙烯基,2-噻吩基,3-吡啶基,4-吡啶基,2-吡啶基,3-吲哚甲基,3-吲哚丙基)。生物活性测试表明,部分化合物具有一定的抗癌活性。

关 键 词:苄基P  有机锡化合物  氧化物  杂环化合物  羧酸酯  生物活性  结构表征
修稿时间:1999-07-14

Synthesis and characterization of bis(dibenzylstannic heteroaromatic redical carboxylate) oxide
YIN Han-Dong,WANG Chuan-Hua,WANG Yong,MA Chun-Lin.Synthesis and characterization of bis(dibenzylstannic heteroaromatic redical carboxylate) oxide[J].Chinese Journal of Organic Chemistry,2000,20(3):415-418.
Authors:YIN Han-Dong  WANG Chuan-Hua  WANG Yong  MA Chun-Lin
Institution:YIN Han-Dong ,WANG Chuan-Hua ,WANG Yong ,MA Chun-Lin (Department of Chemistry,Liaocheng Teachers University, 252059 Liaocheng)
Abstract:Eight new bis(dibenzylstannic heteroaromatic radical carboxylate)oxides (R - 2 - furanyl, 2 - furanvinyl, 2 - thiophenyl, 3 - pyridyl, 4 - pyridyl, 2 - pyridyl, 3 - indolymethyl, 3 - indolypropyl) were synthesized by the reaction of dibenzylstannic oxide with heteroarmotic radical substituted carboxylic acids in 1 : 1 molar ratio. The compounds were characterized by elemental analysis, MS,IR and NMR(1H, Sn). These results revealed that the compounds adopt the dicarboxylate tetraorganodistannoxane structure mode and the four carboxylate ligande were coordinated to Sn in bidentate. The 119Sn NMR spectroscopy indicated the presence of two distinct sixcoordinate tin centers. The compounds were tested in vitro against two human tumour cell lines, MCF - 7, a mammary tumour, and WiDr, a colon carcinoma. Some of them showed antitumor activities.
Keywords:dibenzylstannic oxide  hetermotic racical carboxylic scid  synthesis  biological activity
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