| 三氯化铁催化的—锅法合成3,4-二氢嘧啶-2-酮 |
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| 引用本文： | 路军,马怀让,李万华.三氯化铁催化的—锅法合成3,4-二氢嘧啶-2-酮[J].有机化学,2000(5). |
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| 作者姓名： | 路军 马怀让 李万华 |
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| 作者单位： | 西北大学化学系，西北大学化学系，西北大学化工系 西安 710069，西安 710069，西安 710069 |
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| 基金项目： | 西北大学科研基金(98NW07F) |
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| 摘 要： | 六水合三氯化铁催化下,β-酮酸酯、芳香醛、脲(1:1:1.5)在无水乙醇中进行环化缩合反应,合成了3,4-二氢嘧啶-2-酮衍生物,改进了Biginelli用盐酸为催化剂的一锅法反应,缩短了反应时间,操作简便,产率高达80％～90％,且Fe~(3 )对环境友好。
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| 关 键 词： | Biginelli反应 3 4-二氢嘧啶-2-酮 三氯化铁 一锅法 |
A Novel One - Pot Synthesis of 3,4 - Dihydropyrimidine - 2(1H) -Ones by Catalyzed Ferric Chloride Hexahydrate |
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| LU Jun,MA Huai-Rang.A Novel One - Pot Synthesis of 3,4 - Dihydropyrimidine - 2(1H) -Ones by Catalyzed Ferric Chloride Hexahydrate[J].Chinese Journal of Organic Chemistry,2000(5). |
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| Authors: | LU Jun MA Huai-Rang |
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| Abstract: | The syntheses of dihydropyrimidinones by a one - pot cyclocondensation of aldehydes,B - keto ester, and ureas ( 1 : 1 : 1 . 5 ) using ferric chloride hexahydrate as catalyst and alcohol as solvent are presented . The modified one - pot Biginelli's cyclocondensation not only features short reaction period, simple operation and high yield (80% -90%), but also is environment friendly. |
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| Keywords: | Biginelli reaction dihydropyrimidine - 2( 1H)- ones ferric chloride hexahydrate one - pot process |
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