| 3-取代苄氧基-6-(取代-1H-吡唑-1-基)哒嗪的合成与生物活性 |
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| 引用本文： | 胡方中,张桂峰,邹小毛,刘斌,朱有全,杨华铮.3-取代苄氧基-6-(取代-1H-吡唑-1-基)哒嗪的合成与生物活性[J].有机化学,2008,28(7):1227-1232. |
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| 作者姓名： | 胡方中 张桂峰 邹小毛 刘斌 朱有全 杨华铮 |
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| 作者单位： | 南开大学元素有机化学国家重点实验室,元素有机化学研究所,天津,300071 |
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| 基金项目： | 国家"973"计划，国家自然科学青年基金(No.20302004)助项目 |
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| 摘 要： | 3-氯-6-肼基哒嗪分别与乙酰丙酮和3-二甲胺基丙烯醛反应, 合成了中间体3-氯-6-(3,5-二甲基-1H-吡唑-1-基)哒嗪(2)和3-氯-6-(1H-吡唑-1-基)哒嗪(4), 它们与多种取代苄醇反应, 得到了一系列未见报道的3-取代苄氧基-6-(取代-1H-吡唑-1-基)哒嗪, 其结构均经1H NMR, IR和元素分析确证. 初步的生物活性测试结果表明, 所合成的化合物对油菜和稗草均具有一定的抑制作用.
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| 关 键 词： | 哒嗪 合成 除草活性 |
| 收稿时间： | 2007-7-19 |
| 修稿时间： | 2007-12-7 |
Synthesis and Biological Activity of 3-(Substituted benzyloxy)- 6-[(un)substituted 1H-prazol-1-yl]pyridazines |
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| Institution: | (State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry,
Nankai University, Tianjin 300071)
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| Abstract: | A series of novel 3-(substituted benzyloxy)-6-(un)substituted 1H-pyrazol-1-yl]pyridazine derivatives were synthesized through the condensation of various substituted benzyl alcohols with 3-chloro-6-(3,5-dimethyl-1H-pyrazole-1-yl)pyridazine (2) or 3-chloro-6-(1H-pyrazol-1-yl)pyridazine (4). 2 and 4 were obtained from the cyclization of 3-chloro-6-hydrazinylpyridazine with acetoacetone and/or 3-dimethylamino acrolein. The structures of the title compounds were identified by 1H NMR, IR spectra and elemental analysis. Preliminary bioassay showed that all of them possessed some extent herbicidal activity against Brassica campestris and Echinochloa crusgalli. |
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| Keywords: | pyridazine synthesis herbicidal activity |
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