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| 钯催化合成嘧啶核苷衍生物的研究进展 | |
| 引用本文： | 靳玄烨,肖强,巨勇.钯催化合成嘧啶核苷衍生物的研究进展[J].有机化学,2009,29(1):44-54. |
| 作者姓名： | 靳玄烨 肖强 巨勇 |
| 作者单位： | 1. 清华大学化学系,生命有机磷与化学生物学教育部重点实验室,北京,100084 2. 江西科技师范学院有机功能分子重点实验室,南昌,330013 |
| 基金项目： | 国家自然科学基金，教育部科学技术研究项目重点项目，人事部留学回国人员择优项目，江西科技师范学院青年创新基金 |
| 摘 要： | 嘧啶核苷衍生物在药物化学、生物探针和核酸化学的研究中具有重要的作用, 金属催化碳碳的形成广泛应用于嘧啶核苷衍生物的合成. 综述了钯催化的Sonogashira反应、Stille反应、Heck反应以及Hiyama反应在嘧啶类核苷衍生物合成中的应用. |
| 关 键 词： | 嘧啶核苷 Sonogashira反应 Stille反应 Heck反应 Hiyama反应 |
| 收稿时间： | 2007-11-8 |
| 修稿时间： | 2008-6-3 |
Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives |
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| Jin,Xuanye,Xiao,Qiang,Ju,Yong.Progress in Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Derivatives[J].Chinese Journal of Organic Chemistry,2009,29(1):44-54. | |
| Authors: | Jin Xuanye Xiao Qiang Ju Yong |
| Institution: | (a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084) (bJiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013) |
| Abstract: | Pyrimidine nucleosides are of great importance for medicinal chemistry, biological probe and nucleic acid. Palladium-catalyzed formation of carbon-carbon bond has found broad application to the synthesis of pyrimidine nucleoside derivatives. In this paper, the application and mechanism of some important palladium-catalyzed reactions used for the synthesis of pyrimidine nucleoside derivatives are summarized, which include Sonogashira reaction, Stille reaction, Heck reaction and Hiyama reaction. |
| Keywords: | pyrimidine nucleoside Sonogashira reaction Stille reaction Heck reaction Hiyama reactio |
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