| 1,4-二氢-4-芳基-3,5-吡啶二羧酸酯的合成及表征 |
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| 引用本文： | 伍小云,胡艾希,谢艳丽.1,4-二氢-4-芳基-3,5-吡啶二羧酸酯的合成及表征[J].有机化学,2006,26(1):93-98. |
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| 作者姓名： | 伍小云 胡艾希 谢艳丽 |
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| 作者单位： | 1. 湖南大学化学化工学院,化学生物传感与计量国家重点实验室,长沙,410082
2. 湖南大学化学化工学院,化学生物传感与计量国家重点实验室,长沙,410082;华南理工大学化工与能源学院,广东省绿色化学产品技术重点实验室,广州,510640 |
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| 基金项目： | 湖南大学化学生物传感与计量国家重点实验室开放基金资助项目. |
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| 摘 要： | 基于二氢吡啶化合物的构效关系, 设计了一系列1,4-二氢-4-芳基-3,5-吡啶二羧酸酯新化合物. 含有易于水解基团的1,4-二氢-4-芳基-3,5-吡啶二羧酸酯类化合物在碱性条件下水解合成了重要中间体1,4-二氢-4-芳基-3,5-吡啶二羧酸单酯, 收率93%～99.8%. 该二羧酸单酯与α-溴代芳基乙酮在相转移剂催化下反应合成目标化合物, 收率74%～99%. 中间体和目标化合物经1H NMR, 13C NMR, IR, MS和元素分析等确证.
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| 关 键 词： | 1 4-二氢-4-芳基-3 5-吡啶二羧酸酯 合成 表征 相转移催化 |
| 收稿时间： | 01 11 2005 12:00AM |
| 修稿时间： | 07 12 2005 12:00AM |
Synthesis and Characterization of 4-Aryl-1,4-dihydropyri-dine-3,5-dicarboxylates |
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| WU,Xiao-Yun,HU,Ai-Xi,XIE,Yan-Li.Synthesis and Characterization of 4-Aryl-1,4-dihydropyri-dine-3,5-dicarboxylates[J].Chinese Journal of Organic Chemistry,2006,26(1):93-98. |
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| Authors: | WU Xiao-Yun HU Ai-Xi XIE Yan-Li |
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| Institution: | a. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082;b. Guangdong Provincial Laboratory of Green Chemical Technology, School of Chemical and Energy Engineering, South China University of Technology, Guangzhou 510640 |
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| Abstract: | New 4-aryl-1,4-dihydropyridine-3,5-dicarboxylates were designed and synthesized by the reaction of 1,4-dihydro-3,5-pyridinedicarboxylic monoesters with α-bromoarylketones by phase transfer catalysis in 74%～99%. The 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylic monoesters were prepared by the hydrolysis of 4-aryl-5-(2'-cyanoethyl)-1,4-dihydro-3,5-pyridine dicarboxylates with yields of 93%～99.8%. The intermediates and target compounds were characterized by 1H NMR, 13C NMR, IR, MS spectra and elemental analyses. |
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| Keywords: | 4-aryl-1 4-dihydro-3 5-pyridinedicarboxylate synthesis characterization phase transfer ca-talysis |
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