| Abstract: | Ligand design and synthesis occupy a central theme in asymmetric catalysis. 1] In developing chiral ligands, their design should provide an opportunity for tuning through easy modification of substituents. In a large number of cases, this means starting from a new chiral source. We have been interested in design/synthesis of novel chiral ligands that allow for diversity to be introduced with ease. We have designed a new ligand system containing a core dihydropyrazole moiety with chiraliuy residing remotely to the fluxional group as shown in Scheme 1. There are three points of diversity and these are indicated on the structure. |
