新型线粒体氧还酶抑制剂型分子探针: 叠氮水杨酰胺类化合物的合成

以硝基水杨酰胺经还原，重氮化，叠氮化反应合成了五个新的叠氮水杨酰胺类化合物。通过还原反应的研究发现，侧链较短的硝基水杨酰胺用Sn+HCl还原效果较好。侧链较长的硝基水杨酰胺用H~2-Pd/C催化加氢还原效果较好。产品结构经IR，^1H NMR，MS和元素分析确定。合成的新叠氮水杨酰胺类化合物可以作为线粒体呼吸链酶的抑制剂型分子探针。

Synthesis of azidosalicylamides: A new molecular probe of mitochondrial oxido-reductase inhibitor type

A new group of azidosalicylamides were prepared from nitrosalicylamides by means of reduction, diazotizaion and azidolation. The nitrosalicylamides with a shorter chain may be reduced by Sn HCl, whereas the nitrosalicylamides with a longer side chain may be reduced by H2 - Pd/C in good yields. The structures of the products obtained were characterized by IR,1HNMR, Mass spectra and elemental analysis. The new azidosalicylamides synthesized have been used successfully as a new type of molecular probe for mitochondrial respiratory chain enzymes study.