微波干法合成脱氧胆酸分子钳人工受体

在微波辐射无溶剂条件下, 以固体K₂CO₃为载体, 脱氧胆酸甲酯与芳酰氯反应合成了11个脱氧胆酸分子钳人工受体, 其中5个为新化合物, 所有化合物的结构均经¹H NMR, IR, MS及元素分析所确证. 同传统方法相比, 该法具有简单、安全、快速、有效、对环境友好等优点. 同时考察了这类受体对中性和手性分子的识别性能. 结果表明, 这类分子钳受体不但对中性分子具有识别性能, 而且对D/L-氨基酸甲酯具有对映选择性识别性能.

Solvent-Fee Synthesis of Molecular Tweezer Artificial Recep-torsDerived from Deoxycholic Acid under Microwave Irradiation

Eleven molecular tweezer artificial receptors based on deoxycholic acid have been synthesized by using solid K_2CO_3 as supporter through the reaction of methyl deoxycholate with aroyl chloride in sol- vent-free conditions under microwave irradiation,five of which are new compounds.The structures of all the molecular tweezers were characterized by ~1H NMR,IR,MS spectra and elemental analysis.Compared with the conventional method,this method is simple,safe,rapid,efficient and eco-friendly.The recognition properties of these molecular tweezers for neutral molecules and chiral molecules were investigated.The re- sults indicate that these molecular tweezers not only recognize neutral organic molecules but also have good enantioselectivity to D/L-amino acid methyl esters.