| 无溶剂条件下微波辐射合成2-氨基噻唑衍生物 |
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| 引用本文： | 成冲云,姜凤超.无溶剂条件下微波辐射合成2-氨基噻唑衍生物[J].有机化学,2005,25(7):826-829. |
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| 作者姓名： | 成冲云 姜凤超 |
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| 作者单位： | 华中科技大学同济医学院药学院,武汉,430030 |
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| 摘 要： | 在无溶剂条件下, 用微波辐射法以碘、酮和硫脲为原料合成了9个2-氨基噻唑衍生物. 利用正交法优化了微波促进此类环化反应的最佳条件, 提出了微波条件下碘催化环化合成2-氨基噻唑衍生物可能的反应机理.
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| 关 键 词： | 2-氨基噻唑衍生物 合成 微波辐射 环化反应 反应机理 |
| 收稿时间： | 2004-10-15 |
| 修稿时间： | 2005-1-24 |
Solvent Free Synthesis of 2-Aminothiazole Derivatives under Microwave Irradiation |
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| CHENG Chong-Yun,JIANG Feng-chao.Solvent Free Synthesis of 2-Aminothiazole Derivatives under Microwave Irradiation[J].Chinese Journal of Organic Chemistry,2005,25(7):826-829. |
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| Authors: | CHENG Chong-Yun JIANG Feng-chao |
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| Institution: | (School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030) |
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| Abstract: | Nine 2-aminothiazole derivatives were obtained under microwave irradiation condition by the reaction of thiourea, iodine and ketone in the absence of solvent. The reaction conditions were optimized by orthogonal design. The mechanism of the cyclization reaction under microwave irradiation was also suggested. |
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| Keywords: | 2-aminothiazole synthesis microwave irradiation cyclization reaction mechanism |
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