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| E/Z-焦脱镁叶绿酸-a 甲酯131-酮肟的合成及其烷(酰)基化反应 | |
| 引用本文： | 王进军,纪建业,韩光范,沈荣基,森章,初井敏一.E/Z-焦脱镁叶绿酸-a 甲酯131-酮肟的合成及其烷(酰)基化反应[J].有机化学,2004,24(1):53-58. |
| 作者姓名： | 王进军 纪建业 韩光范 沈荣基 森章 初井敏一 |
| 作者单位： | 1. 烟台大学应用化学系,烟台,264005 2. 通化师范学院化学系,通化,134002 3. 华东船舶工业学院材料科学工程系,镇江,212003 4. 韩国化学研究所,韩国 5. 九州大学机能物质研究所,日本 |
| 摘 要： | 以焦脱镁叶绿酸-a 甲酯(MPP-a)为起始原料,通过E环羰基与盐酸羟胺反应,生成Z/E顺反结构的焦脱镁叶绿酸-a 甲酯酮肟异构体,分离后与酰卤和卤代烷反应,分别生成Z或者E型O-烷酰基酮肟和O-烷基酮肟.所合成新的二氢卟吩衍生物均经UV, IR, 1H NMR, 13C NMR及元素分析证实其结构. |
| 关 键 词： | 焦脱镁叶绿酸-a 甲酯 E/Z-焦脱镁叶绿酸-a 甲酯E环酮肟 烷基化 酰基化 光动力疗法 |
| 修稿时间： | 2003年4月18日 |
Synthesis of E/Z-131-Ketoxime Isomers of Methyl Pyropheophorbide-a and Their Alkylation and Acylation |
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| WANG,Jin-Jun,a JI,Jian-Ye b HAN,Guang-Fan c SHIM Young Key d Mori Akiro e Hatsui Toshihide e.Synthesis of E/Z-131-Ketoxime Isomers of Methyl Pyropheophorbide-a and Their Alkylation and Acylation[J].Chinese Journal of Organic Chemistry,2004,24(1):53-58. | |
| Authors: | WANG Jin-Jun a JI Jian-Ye b HAN Guang-Fan c SHIM Young Key d Mori Akiro e Hatsui Toshihide e |
| Abstract: | Methyl pyropheophorbide-a (MPP-a) was used as starting material for the synthesis of new chlorin compounds. The Z/E-ketoxime isomers of methyl pyropheophorbide-a were obtained by reaction of carbonyl group at 13 1-position with hydroxylamine. The alkylation and acylation of E/Z-ketoximes were carried out by the reaction with alkyl halide and acyl halide to give Z- or E-O-aralkyl ketoxime and O-aroyl (acetyl) ketoxime, respectively. The structures of all these compounds were characterized by elemental analysis, UV, IR, 13C NMR and 1H NMR spectra. |
| Keywords: | methyl pyropheophorbide-a E/Z-13 1-ketoxime of methyl pyropheophorbide-a alkylation acylation photodynamic therapy |
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