| 系列缩水甘油醚类β-环糊精衍生物的合成及结构表征 |
| |
| 引用本文： | 张毅民,陈春凤,孙聪善,李潇.系列缩水甘油醚类β-环糊精衍生物的合成及结构表征[J].有机化学,2007,27(8):1022-1026. |
| |
| 作者姓名： | 张毅民 陈春凤 孙聪善 李潇 |
| |
| 作者单位： | 天津大学化工学院绿色合成与转化教育部重点实验室,天津,300072 |
| |
| 摘 要： | 以苯基缩水甘油醚、邻甲基酚缩水甘油醚及苯甲基缩水甘油醚(1～3)和β-环糊精为原料, 分别在弱碱水溶液(1.5%)和强碱水溶液(30%)中制备出系列缩水甘油醚类β-环糊精衍生物, 所得产物用自制硅胶色谱柱分离, 以V(正丙醇)∶V(水)∶V(浓氨水)＝6∶3∶1作为硅胶色谱柱分离纯化的洗脱剂, 得到单2位取代的苯氧基(或邻甲基苯氧基或苯甲氧基-2-羟丙基-β-环糊精(1a～3a)和单6位取代的苯氧基(或邻甲基苯氧基)-2-羟丙基-β-环糊精(1b～2b). 所得产品用薄层色谱、红外光谱、质谱和核磁共振波谱等手段进行了表征.
|
| 关 键 词： | β-环糊精 缩水甘油醚 薄层色谱 质谱 核磁共振波谱 |
| 收稿时间： | 2006-9-26 |
| 修稿时间： | 2006-09-262006-12-28 |
Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives |
| |
| ZHANG,Yi-Min,CHEN,Chun-Feng,SUN,Cong-Shan,LI,Xiao.Synthesis and Characterization of Glycidyl Ether Modified β-Cyclodextrin Derivatives[J].Chinese Journal of Organic Chemistry,2007,27(8):1022-1026. |
| |
| Authors: | ZHANG Yi-Min CHEN Chun-Feng SUN Cong-Shan LI Xiao |
| |
| Institution: | Key Laboratory for Green Chemical Technology of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072 |
| |
| Abstract: | Using phenyl glycidyl ether (1), 2-methylphenyl glycidyl ether (2), benzyl glycidyl ether (3) and β-cyclodextrin as raw materials, in 1.5% (m/V) and 30% (m/V) sodium hydroxide solution, novel β-cyclodextrin derivatives have been synthesized. The products were isolated by using proper eluent V(1-propanol)∶V(water)∶V(concd aq ammonia)＝6∶3∶1 through a self packed silica gel column chro-matography, and their chemical structures were proved to be mono 2-substituted phenoxy (or 2-methylphenoxy or benzyloxy)-2-hydroxypropyl-β-cyclodextrin (1a～3a) and mono 6-substituted phenoxy (or 2-methylphenoxy)-2-hydroxypropyl-β-cyclodextrin (1b～2b) by means of TLC, IR, MS, 1H NMR and 13C NMR spectra. |
| |
| Keywords: | β-cyclodextrin glycidyl ether thin-layer chromatography (TLC) mass spectrometry nuclear magnetic resonance spectroscopy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《有机化学》浏览原始摘要信息 |
| 点击此处可从《有机化学》下载免费的PDF全文 |
|
