| 4-取代-脯氨醇催化的前手性酮不对称硼烷还原 |
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| 引用本文： | 张雅文,梁静,陆军,郭聪琳,沈宗旋.4-取代-脯氨醇催化的前手性酮不对称硼烷还原[J].有机化学,2000,20(3):334-337. |
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| 作者姓名： | 张雅文 梁静 陆军 郭聪琳 沈宗旋 |
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| 作者单位： | 苏州大学化学化工学院,苏州,215006 |
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| 基金项目： | 国家自然科学基金(批准号2972061)和江苏省教委自然科学基金资助项目。 |
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| 摘 要： | (2S)-(二苯基羟甲基)-(4S)-苯氧基-四氢吡咯(10)由羟脯氨酸(6)经4步反应制得。用10催化6种前手性酮的不对称硼烷还原反应,其结果与(S)-二苯基脯氨醇催化的同一反应的结果进行了对比。
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| 关 键 词： | 脯氨醇 羟脯氨酸 前手性酮 硼烷 氧氮硼五环 五员杂环化合物 选择还原 不对称反应 手征性 |
| 修稿时间： | 1999-03-30 |
Asymmetric borane reduction of prochiral ketones catalyzed by 4- substituted prolinol |
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| ZHANG Ya-Wen,LIANG Jing,LU Jun,GUO Cong-Lin,SHEN Zong-Xuan.Asymmetric borane reduction of prochiral ketones catalyzed by 4- substituted prolinol[J].Chinese Journal of Organic Chemistry,2000,20(3):334-337. |
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| Authors: | ZHANG Ya-Wen LIANG Jing LU Jun GUO Cong-Lin SHEN Zong-Xuan |
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| Institution: | ZHANG Ya-Wen
,LIANG Jing
,LU Jun
,GUO Cong-Lin
,SHEN Zong-Xuan
(School of Chemistry and Chemical Engineering, Suzhou University, 215006 Suzhou) |
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| Abstract: | (2S) - (diphenylhydroxymethyl) - (4S) - phenoxy - pyrrolidine 10 was prepared from hydroxyproline 6 via a four - step sequence. Using 10 as the catalyst, six prochiral ketones were reduced enantioselectively with borane and the results were compared with those with 1,1- diphenylprolinol as catalys. |
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| Keywords: | chiral 1 3 2-oxazaborohdine enantioselective reduction prochiral ketone |
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