| 6-取代苄硫基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑[3,4-b][1,3,4]噻二唑类化合物的合成与抑菌活性 |
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| 引用本文： | 杜海堂,桑维钧,王慧.6-取代苄硫基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑[3,4-b][1,3,4]噻二唑类化合物的合成与抑菌活性[J].有机化学,2012,31(8):1539-1542. |
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| 作者姓名： | 杜海堂 桑维钧 王慧 |
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| 作者单位： | 1. 贵阳学院化学系 贵阳550005
2. 贵州大学农学院 贵阳550025 |
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| 基金项目： | 贵州省科学技术基金，贵州省教育厅自然科学基金，贵阳市人才创新创业 |
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| 摘 要： | 以4-氨基-5-(3,4,5-三甲氧基苯基)-3-巯基-1,2,4-三唑为原料,环化得到6-巯基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑3,4-b]1,3,4]噻二唑再与取代苄氯反应,得到9个6-取代苄硫基-3-(3,4,5-三甲氧基苯基)-1,2,4-三唑3,4-b]1,3,4]噻二唑类衍生物3a～3i.其结构经IR,1H NMR,MS和元素分析确证.初步生物活性测试结果表明部分化合物有一定的杀菌活性.
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| 关 键 词： | 4-氨基-3-巯基-1 2 4三唑 三唑并噻唑 杀菌活性 |
Synthesis and Fungicidal Activity of 6-(Substituted benzylthio)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b] [1,3,4]thiadiazole |
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| Du Haitang
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Sang Weijun
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Wang Hui.Synthesis and Fungicidal Activity of 6-(Substituted benzylthio)-3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo[3,4-b] [1,3,4]thiadiazole[J].Chinese Journal of Organic Chemistry,2012,31(8):1539-1542. |
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| Authors: | Du Haitang Sang Weijun Wang Hui |
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| Institution: | Du,Haitang a Sang,Weijun b Wang,Hui b(a Department of Chemistry,Guiyang College,Guiyang 550005)(b College of Agriculture,Guizhou University,Guiyang 550025) |
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| Abstract: | 3-(3,4,5-Trimethoxyphenyl)-1,2,4-triazolo3,4-b]1,3,4]thiadiazole-6-thiol(2) has been obtained by the cyclization of 4-amino-5-(3,4,5-trimethoxybenzyl)-3-sulfydryl-1,2,4-triazole(1) with carbon disulfide in the presence of potassium hydroxide.Then the target compounds 3a～3i were prepared from 3-(3,4,5-trimethoxyphenyl)-1,2,4-triazolo3,4-b]-1,3,4]thiadiazole-6-thiol with various substituted benzyl chlorides.Their structures were confirmed by IR,1H NMR,MS techniques and elemental analysis,and fungicidal activity was studied as well.Preliminary bioassay test indicated that some of the compounds had obvious fungicidal activity. |
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| Keywords: | 4-amino-3-sulfydryl-1 2 4-triazole triazolo thiadiazole fungicidal activity |
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