| 4(3H)-喹唑啉酮类Schiff碱的合成与抗烟草花叶病毒活性 |
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| 引用本文： | 高兴文,蔡学建,严凯,高丽丽,王和英,陈卓,宋宝安.4(3H)-喹唑啉酮类Schiff碱的合成与抗烟草花叶病毒活性[J].有机化学,2008,28(10):1785-1791. |
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| 作者姓名： | 高兴文 蔡学建 严凯 高丽丽 王和英 陈卓 宋宝安 |
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| 作者单位： | 贵州人学精细化上研究开发中心教育部绿色农药与农业生物上程重点实验室,贵阳,550025 |
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| 基金项目： | 国家自然科学基金，国家科技支撑计划，贵州省工业科技攻关项目 |
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| 摘 要： | 采用邻氨基苯甲酸经醋酐酰化闭环得2-甲基苯并噁嗪-4-酮, 水合肼回流合成2-甲基-3-氨基-4(3H)-喹唑啉酮, 在无水乙醇中与芳醛反应得4(3H)-喹唑啉酮类Schiff碱. 经元素分析, IR, 1H NMR, 13C NMR对所合成的化合物进行了结构确认和表征. 初步生物活性测试表明, 化合物3t具有较高的抗烟草花叶病毒活性.
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| 关 键 词： | 4(3H)-喹唑啉酮 Schiff碱 合成 抗烟草花叶病毒活性 |
| 收稿时间： | 2007-10-25 |
| 修稿时间： | 2008-2-14 |
Synthesis and Anti-tobacco Mosaic Virus Activity of 4(3H)-Quinazolinone Schiff Base |
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| GAO,Xing-Wen,CAI,Xue-Jian,YAN,Kai,GAO,Li-Li,WANG,He-Ying,CHEN,Zhuo,SONG,Bao-An.Synthesis and Anti-tobacco Mosaic Virus Activity of 4(3H)-Quinazolinone Schiff Base[J].Chinese Journal of Organic Chemistry,2008,28(10):1785-1791. |
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| Authors: | GAO Xing-Wen CAI Xue-Jian YAN Kai GAO Li-Li WANG He-Ying CHEN Zhuo SONG Bao-An |
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| Institution: | (Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Research and
Development Center of Fine Chemicals, Guizhou University, Guiyang 550025)
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| Abstract: | Starting from anthranilic acid, 4(3H)-quinazolinone Schiff base derivatives 3 were synthesized by a three-step process. Cyclization reaction of anthranilic acid with acetic anhydride afforded 2-methyl-3,1- benzoxazin-4-one 1, in which was then converted into the intermediate 2 by hydrazination reaction. Con-densation reaction of substituted benzaldehyde with 3-amino-2-methyl-4(3H)-quinazolinone 2 in a refluxing ethanol gave the 4(3H)-quinazolinone Schiff base. Their structures of 3 were established by elemental analysis, IR, 1H NMR and 13C NMR spectra. The bioassay of title compound 3t showed that it had good anti-tobacco mosaic virus activity. |
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| Keywords: | 4(3H)-quinazolinone Schiff base moiety synthesis anti-TMV activity |
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