| 四氢苯并[4',5']噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮的合成、晶体结构及杀菌活性 |
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| 引用本文： | 任青云,贺红武,刘建超.四氢苯并[4',5']噻吩并[3',2':5,6]吡啶并[4,3-d]嘧啶-4(3H)-酮的合成、晶体结构及杀菌活性[J].有机化学,2007,27(3):397-401. |
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| 作者姓名： | 任青云 贺红武 刘建超 |
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| 作者单位： | 华中师范大学有机合成研究所,教育部农药与化学生物学重点实验室,武汉,430079 |
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| 基金项目： | 国家重点基础研究发展规划973计划（No.2003CB114-400）及国家自然科学基金（No.20372023）资助项目. |
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| 摘 要： | 通过氮杂Wittig反应合成了一系列结构新颖的未见文献报道的取代四氢苯并4',5']噻吩并3',2':5,6]吡啶并4,3-d]嘧啶-4(3H)-酮化合物6, 产物的结构通过核磁共振氢谱、质谱、红外光谱、元素分析的确证. 为进一步了解此类化合物的结构, 对化合物6c进行了X射线单晶衍射. 初步杀菌活性测定结果表明, 该类化合物具有较好的杀菌活性和选择性. 如6f在50 mg/L浓度时, 对黄瓜灰霉菌的抑制率为98%.
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| 关 键 词： | 吡啶并[4 3-d]嘧啶 氮杂Wittig反应 合成 晶体结构 杀菌活性 |
| 收稿时间： | 2006-2-20 |
| 修稿时间： | 2006-02-20 |
Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4',5']thieno[3',2':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives |
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| REN Qing-Yun,HE Hong-Wu,LIU Jian-Chao.Synthesis, Crystal Structure and Fungicidal Activity of Tetrahydro-benzo[4'',5'']thieno[3'',2'':5,6]pyrido[4,3-d]pyrimidin-4(3H)-one Derivatives[J].Chinese Journal of Organic Chemistry,2007,27(3):397-401. |
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| Authors: | REN Qing-Yun HE Hong-Wu LIU Jian-Chao |
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| Institution: | (Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Institute of Organic Synthesis,Central China Normal University, Wuhan 430079) |
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| Abstract: | A series of new tetrahydrobenzo4',5']thieno3',2':5,6]pyrido4,3-d]pyrimidin-4(3H)-one deriva- tives 6 have been designed and synthesized via a tandem aza-Wittig reaction. The structures of all com- pounds prepared have been comfirmed by 1H NMR, IR, EI-MS spectra, elemental analysis as well as X-ray diffraction analysis for 6c. Biological test showed that some of the target compounds displayed good fungicidal activity. For example, 6f exhibited 98% inhibition of Botrytis cinerea Pers. in 50mg/L. |
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| Keywords: | pyrido[4 3-d]pyrimidin aza-Wittig reaction synthesis crystal structure fungicidal activity |
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