| 二氢卟吩P6醚类衍生物的合成 |
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| 引用本文： | 姚建忠,刘建飞,张万年,周有骏,朱驹,吕加国,王小燕,李科.二氢卟吩P6醚类衍生物的合成[J].有机化学,2001,21(6):458-462. |
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| 作者姓名： | 姚建忠 刘建飞 张万年 周有骏 朱驹 吕加国 王小燕 李科 |
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| 作者单位： | 第二军医大学药学院 |
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| 基金项目： | 国家自然科学基金资助项目(No.39522003). |
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| 摘 要： | 以蚕沙糊状叶绿素经酸碱降解制得的二氢卟吩P6三甲酯(2)为关键中间体，设计合成了9个二氢卟吩P6醚类衍生物3a～3e和4b～4e，用UV、IR、^1H、NMR、FAB-MS和元素分析确证了它们的结构。
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| 关 键 词： | 蚕沙 叶绿素 二氢卟酚 醚 紫外分光光度法 红外分光光度法 质子磁共振谱法 元素分析 |
| 修稿时间： | 2000年11月20 |
Synthesis of chlorin P6 ether derivatives |
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| Institution: | Univ of No.2 Military Medicine, College of Pharmacy.Shanghai |
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| Abstract: | Nine chlorin P6 ether derivatives (3a～3e and 4b～4e) were designed and synthesized via HBr addition of 2-vinyl of chlorin P6 trimethylester (2), which was prepared through acidic and alkaline oxidative degradation using silkworm excrement crude chlorophyll extracts as starting material followed by H2O, MeOH, EtOH, n-C3H7OH, CH2=CHCH2OH nucleophilic substitution and hydrolysis respectively. All these compounds are previously unknown. Their structures were assigned based on the data derived from UV, IR, ^1H NMR, FAB-MS and elemental analysis. |
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| Keywords: | SILKWORM LITTER CHLOROPHYLL ETHER ULTRAVIOLET SPECTROPHOTOMETRY INFRARED SPECTROPHOTOMETRY PROTON MAGNETIC RESONANCE SPECTROMETRY ELEMENTAL ANALYSIS |
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