| 含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究 |
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| 引用本文： | 孟凡领,郑昌吉,李因晶,孙良鹏,刘学坤,张天一,朴虎日.含噻唑烷二酮-3-乙酸结构查尔酮衍生物的合成及抗菌活性的研究[J].有机化学,2012,32(1):183-188. |
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| 作者姓名： | 孟凡领 郑昌吉 李因晶 孙良鹏 刘学坤 张天一 朴虎日 |
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| 作者单位： | 延边大学药学院 长白山生物资源与功能分子教育部重点实验室 延吉133002 |
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| 摘 要： | 合成了一系列含噻唑烷二酮-3-乙酸结构的新型查尔酮衍生物,并对化合物进行了抗菌活性测定.结果显示,一些化合物对4种多重耐药菌显示出较强的抗菌活性,其中化合物8g,8i,8l和8m在抗耐甲氧西林金黄色葡萄球菌的最小抑制浓度(MIC)达到4μg/mL,与对照药诺氟沙星(norfloxacin)相当.另外,在64μg/mL浓度下,所有化合物对大肠杆菌1356均无明显抑制活性.
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| 关 键 词： | 查尔酮 噻唑烷二酮-3-乙酸 抗菌活性 |
Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety |
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| Meng,Fanling
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Zheng,Changji
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Li,Yinjing
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Sun,Liangpeng
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Liu,Xuekun
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Zhang,Tianyi
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Piao,Huri.Synthesis and Anti-bacterial Activity of Novel Chalcone Derivatives Containing 2,4-Thiazolidinedione-3-acetic Acid Moiety[J].Chinese Journal of Organic Chemistry,2012,32(1):183-188. |
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| Authors: | Meng Fanling Zheng Changji Li Yinjing Sun Liangpeng Liu Xuekun Zhang Tianyi Piao Huri |
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| Institution: | Meng,Fanling Zheng,Changji Li,Yinjing Sun,Liangpeng Liu,Xuekun Zhang,Tianyi Piao,Huri(Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules,Ministry of Education,College of Pharmacy,Yanbian University,Yanji 133002) |
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| Abstract: | A series of novel chalcone derivatives bearing the 2,4-thiazolidinedione-3-acetic acid moieties(8a～8p) were synthesized,and evaluated for their anti-bacterial activity.The results demonstrated that some compounds presented good antimicrobial activities against four multidrug-resistant clinical isolates,among which compounds 8g,8i,8l and 8m with minimum inhibitory concentration(MIC) value of 4 μg/mL showed as active as the standard drug,norfloxacin,against methi-cillin-resistant S.aureus.None of the compounds exhibited obvious activity against the Gram-negative bacteria E.coli 1356 at 64 μg/mL. |
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| Keywords: | chalcone 2 4-thiazolidinedione-3-acetic acid anti-bacterial activity |
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