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| 红紫素-18的胺解反应及其叶绿素类二氢卟吩衍生物的合成 | |
| 引用本文： | 王朋,杨泽,李家柱,姚楠楠,王进军.红紫素-18的胺解反应及其叶绿素类二氢卟吩衍生物的合成[J].有机化学,2012,32(2):368-375. |
| 作者姓名： | 王朋 杨泽 李家柱 姚楠楠 王进军 |
| 作者单位： | 1. 烟台大学化学化工学院 烟台264005 2. 烟台大学药学院 烟台264005 3. 烟台大学化学化工学院 烟台264005;烟台大学药学院 烟台264005 |
| 摘 要： | 以红紫素-18甲酯为原料,与脂肪胺或者苯胺在加热回流和微波促进的条件下进行胺解反应,分别得到单酰胺化、双酰胺化和羰基亚胺化产物;同时,沿着N21-N23轴向对所得红紫素-18酰亚胺实施化学修饰,分别得到难以分离的具有阻旋异构和差向异构特征的红紫素-18酰亚胺混合物.新的二氢卟吩类衍生物均经UV,IR,1H NMR光谱、质谱及元素分析证明其结构,并对相应的胺解反应提出了可能的反应机理. |
| 关 键 词： | 叶绿素-a 红紫素-18 胺化 红紫素-18内酰胺 合成 |
Aminolysis Reaction of Purpurin-18 and Synthesis of Chlorin Derivatives Related to Chlorophyll |
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| Wang, Peng , Yang, Ze , Li, Jazhu , Yao, Nannan , Wang, Jinjun.Aminolysis Reaction of Purpurin-18 and Synthesis of Chlorin Derivatives Related to Chlorophyll[J].Chinese Journal of Organic Chemistry,2012,32(2):368-375. | |
| Authors: | Wang Peng Yang Ze Li Jazhu Yao Nannan Wang Jinjun |
| Institution: | Wang,Penga Yang,Zea Li,Jazhub Yao,Nannanb Wang,Jinjun*,a,b(a College of Chemistry and Chemical Engineering,Yantai University,Yantai 264005)(b Pharmacy College,Yantai University,Yantai 264005) |
| Abstract: | The aminolysis of purpurin-18 with aliphatic amines or aromatic amines was carried out by reflux and microwave assisted methods to obtain mono-amidated,di-amidated and carbonyl-imidizated products.The chemical modifications of purpurin-18 imides along their N21-N23 axis produced the mixtures of purpurin-18 imides possessing atropisomeric and ano-meric characteritics.The structures of new chlorophyll derivatives were characterized by UV,IR,1H NMR,MS techniques and elemental analysis.The possible mechanisms about aminization reactions were tentatively proposed. |
| Keywords: | chlorophyll-a purpurin-18 amination purpurin-18 imide synthesis |
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