| 多酯基取代的叶绿素类二氢卟吩衍生物的合成 |
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| 引用本文： | 殷军港,王振,杨泽,刘超,赵丽丽,王进军.多酯基取代的叶绿素类二氢卟吩衍生物的合成[J].有机化学,2012,32(2):360-367. |
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| 作者姓名： | 殷军港 王振 杨泽 刘超 赵丽丽 王进军 |
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| 作者单位： | 1. 烟台大学化学化工学院 烟台264005
2. 烟台大学药学院 烟台264005 |
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| 基金项目： | 山东省自然科学基，中匈政府间科技合作 |
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| 摘 要： | 以脱镁叶绿酸-a甲酯为起始原料,通过碱性条件下的水解开环、空气氧化和重排反应,分别合成了红紫素-7三甲酯和二氢卟吩-p6三甲酯.然后对其C(3)-乙烯基、20-meso-位、12-位甲基以及尾端酯基进行化学修饰,通过亲电加成、亲电取代、1,3-偶极环加成和氧化重排等反应,完成10种具未见报道的的叶绿素类二氢卟吩衍生物,其化学结构均经UV,IR,1H NMR光谱及元素分析予以表征.
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| 关 键 词： | 叶绿素-a 脱镁叶绿酸-a甲酯 叶绿素降解 二氢卟吩 化学修饰 合成 |
Synthesis of Multi-ester Substitutied Chlorin Derivatives Related to Chlorophyll-a |
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| Yin, Jungang
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Wang, Zhen
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Yang, Ze
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Liu, Chao
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Zhao, Lili
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Wang, Jinjun.Synthesis of Multi-ester Substitutied Chlorin Derivatives Related to Chlorophyll-a[J].Chinese Journal of Organic Chemistry,2012,32(2):360-367. |
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| Authors: | Yin Jungang Wang Zhen Yang Ze Liu Chao Zhao Lili Wang Jinjun |
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| Institution: | Yin,Junganga Wang,Zhenb Yang,Zea Liu,Chaob Zhao,Lilia Wang,Jinjun*,a(a Colledge of Chemistry and Chemical Engineering,Yantai University,Yantai 264005)(b Pharmacy College,Yantai University,Yantai 264005) |
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| Abstract: | From methyl pheophorbide-a which was used as a starting material,purpurin-7 trimethyl ester and chlorin-p6 trimethyl ester were synthesized by hydrogation-opening ring,allomerization and rearrangement reaction.The synthesis of ten characterized by UV,IR,1H NMR spectra and elemental analysis.unreported chlorin derivatives related to chlorophyll-a was accomplished by electrophilic adduction,electrophilic substitution,1,3-dipolar cycloadduction and oxidation-rearrangement reaction to chemical modifications for C(3)-vinyl group,20-meso-position,methyl group at 12-position and ester moieties at terminal positions.The structures of all new chlorins were characterized by UV, IR,1H NMR spectra and elemental analysis. |
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| Keywords: | chlorophyll-a methyl pheophorbide-a chlorophyll degradation chlorin chemical modification synthesis |
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