N'-(4,5,6-三取代嘧啶-2-基)-2-噻吩磺酰脲的合成

2-氨基-4,5,6-三取代嘧啶和2-噻吩磺酰异氰酸酯发生亲核加成反应, 生成13种含4,5,6-三取代嘧啶环的噻吩磺酰脲,产率高, 它们均为未见文献报道的新化合物.它们的分子结构经^1H NMR, IR和元素分析等测试而得到确证, 并对其生物活性进行了初步研究.

Synthesis of N'-(4,5,6-trisubstitutedpyrimidin-2-ly)-2- thiophenesulfonylureas

Thirteen title compounds (5a～5m) were synthesized by nucleophilic addition of 2-amino-4,5,6-trisubstitutedpyrimidines and 2-thiophenesulfonyl isocyanate in good yields. Their structures were proved by ^1H NMR, IR and elementary analysis and their biologically activities were tested.