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| 微波促进下6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑的合成 | |
| 引用本文： | 朱松磊,屠树江,李团结,章晓镜,纪顺俊,张勇.微波促进下6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶[2,3-c]并吡唑的合成[J].有机化学,2005,25(8):987-990. |
| 作者姓名： | 朱松磊 屠树江 李团结 章晓镜 纪顺俊 张勇 |
| 作者单位： | 1. 徐州师范大学化学系,徐州,221116;徐州医学院化学系,徐州,221002 2. 徐州师范大学化学系,徐州,221116 3. 苏州大学化学化工学院,苏州,215006 |
| 基金项目： | 国家自然科学基金(No.20372057)，江苏省自然科学基金(No.BK2001142)，江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S8109111)，江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目 |
| 摘 要： | 5-氨基-3-甲基-1-苯基吡唑与芳亚甲基丙二腈在少量乙二醇中, 经微波辐射得到6-氨基-4-芳基-5-氰基-3-甲基-1-苯基吡啶2,3-c]并吡唑衍生物, 反应4～8 min完成, 产率为71%～90%, 产物结构通过红外、核磁共振、元素分析及单晶X射线分析表征. |
| 关 键 词： | 吡啶[2 3-c]并吡唑 微波 晶体结构 |
| 收稿时间： | 2004-10-29 |
| 修稿时间： | 2004年10月29 |
Synthesis of 6-Amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino- [2,3-c]pyrazole under Microwave Irradiation |
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| ZHU,Song-Lei,TU,Shu-Jiang,LI,Tuan-Jie,ZHANG,Xiao-Jing,JI,Shun-Jun,ZHANG,Yong.Synthesis of 6-Amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino- [2,3-c]pyrazole under Microwave Irradiation[J].Chinese Journal of Organic Chemistry,2005,25(8):987-990. | |
| Authors: | ZHU Song-Lei TU Shu-Jiang LI Tuan-Jie ZHANG Xiao-Jing JI Shun-Jun ZHANG Yong |
| Institution: | (Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)( Department of Chemistry, Xuzhou Medical College, Xuzhou 221002)( College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006) |
| Abstract: | A series of 6-amino-4-aryl-5-cyano-3-methyl-1-phenylpyridino2,3-c]pyrazole derivatives were synthesized by the reaction of 5-amino-3-methyl-1-phenylpyrazole with arylidene derivatives of malononitrile under microwave irradiation. The reaction was completed in 4～8 min with 71%～90% yields. All the products were characterized by IR, 1H NMR spectra and elemental analysis. 3j was determined by the X-ray diffraction. |
| Keywords: | pyridino[2 3-c]pyrazole microwave crystal structure |
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