| 离子液体功能化二氧化硅催化Knoevenagel反应 |
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| 引用本文： | 厉嘉云,彭家建,邱化玉,蒋剑雄,邬继荣,倪勇,来国桥.离子液体功能化二氧化硅催化Knoevenagel反应[J].有机化学,2007,27(4):483-487. |
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| 作者姓名： | 厉嘉云 彭家建 邱化玉 蒋剑雄 邬继荣 倪勇 来国桥 |
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| 作者单位： | 杭州师范学院有机硅化学及材料技术教育部重点实验室,杭州,310012 |
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| 摘 要： | 在100 ℃, 无外加溶剂条件下, 离子液体功能化二氧化硅催化一系列芳醛和活泼亚甲基化合物进行Knoevenagel 缩合反应, 以高产率生成相应产物. 当反应底物为水杨醛与氰基乙酸乙酯的时候, 产物为3-乙氧基羰基香豆素, 这是水杨醛和氰基乙酸乙酯缩合关环, 再发生氰基醇解的产物. 采用离子液体功能化二氧化硅作为反应催化剂, 反应后催化剂可回收再利用.
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| 关 键 词： | 离子液体 功能化二氧化硅 Knoevenagel反应 |
| 收稿时间： | 2006-6-23 |
| 修稿时间： | 2006-07-31 |
Knoevenagel Condensation Reaction Catalyzed with Ionic Liquid Functionalized SiO2 |
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| LI,Jia-Yun,PENG,Jia-Jian,QIU,Hua-Yu,JIANG,Jian-Xiong,WU,Ji-Rong,NI,Yong,LAI,Guo-Qiao.Knoevenagel Condensation Reaction Catalyzed with Ionic Liquid Functionalized SiO2[J].Chinese Journal of Organic Chemistry,2007,27(4):483-487. |
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| Authors: | LI Jia-Yun PENG Jia-Jian QIU Hua-Yu JIANG Jian-Xiong WU Ji-Rong NI Yong LAI Guo-Qiao |
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| Institution: | Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, Hangzhou Teachers College, Hangzhou 310012 |
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| Abstract: | The Knoevenagel condensation of a series of aromatic aldehydes with active methylene compounds proceeded smoothly in the presence of catalytic amounts of ionic liquid functionalized SiO2 at 100 ℃ without any additional volatile organic solvents, and the desired alkenes were obtained in good purity with excellent yields. In particular, when the Knoevenagel condensation of 2-hydroxybenzaldehyde was conducted with ethyl 2-cyanoacetate, 3-ethoxycarbonylcoumarin was obtained by simultaneous cyclization and alcoholysis of cyanide. In addition, the catalyst can be used recyclably. |
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| Keywords: | ionic liquid functionalized SiO2 Knoevenagel condensation |
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