| 3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展 |
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| 引用本文： | 施展,聂克睿,刘畅,张明智,章维华.3-(噁唑-5-基)吲哚类天然产物生物活性及其衍生物的合成研究进展[J].有机化学,2020(2):327-338. |
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| 作者姓名： | 施展 聂克睿 刘畅 张明智 章维华 |
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| 作者单位： | 南京农业大学理学院;复旦大学化学系 |
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| 基金项目： | 国家自然科学基金(No.21602110);重点研发计划(No.2018YFC1602804);江苏省青年基金(No.BK20160734);中央高校科研基本业务费(Nos.KYTZ201604,KYLH201908)资助项目. |
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| 摘 要： | 3-(噁唑-5-基)吲哚类天然产物如Pimprinine,Streptochlorin等,广泛存在于海洋微生物中,因其具有多样的生物活性,在医药和农药领域中很有研究潜力.3-(噁唑-5-基)吲哚类天然产物的合成方法有很多研究报道,在吲哚结构上构建噁唑环是合成此类天然产物的关键.总结了已报道的3-(噁唑-5-基)吲哚类天然产物的生物活性,并对构建3-(噁唑-5-基)吲哚骨架的合成方法及部分主要反应机理进行了综述,探讨了3-(噁唑-5-基)吲哚类骨架作为一种优势活性结构在未来的应用前景.
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| 关 键 词： | 3-(噁唑-5-基)吲哚 天然产物 生物活性 合成 综述 |
Biological Activities of 3-(5-Oxazolyl) indole Natural Products and Advances on Synthesis of Its Derivatives |
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| Shi Zhan,Nie Kerui,Liu Chang,Zhang Mingzhi,Zhang Weihua.Biological Activities of 3-(5-Oxazolyl) indole Natural Products and Advances on Synthesis of Its Derivatives[J].Chinese Journal of Organic Chemistry,2020(2):327-338. |
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| Authors: | Shi Zhan Nie Kerui Liu Chang Zhang Mingzhi Zhang Weihua |
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| Institution: | (College of Sciences,Nanjing Agricutural University,Nanjing 210095;Department of Chemistry,Fudan University,Shanghai 200433) |
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| Abstract: | 3-(5-Oxazolyl)indole-type natural products such as pimprinine and streptochlorin, widely exist in marine microorganism, because of their diverse biological activity, 3-(5-oxazolyl)indoles show good research and development potential in the field of medicine and pesticide. Numerous studies have been performed to synthesize 3-(5-oxazolyl)indole-type natural products, in which the construction of indole ring and oxazole ring is the most important part. In this paper, the reported natural products with 3-(5-oxazolyl)indole skeleton structure and their biological activities are summarized, and the synthetic methods for 3-(5-oxazolyl)indole skeleton and some of their mechanism are also reviewed. The application prospect of 3-(5-oxazolyl)indole as a dominant active structure in the future was discussed. |
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| Keywords: | 3-(5-oxazolyl)indole natural products biological activities synthesis review |
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