| 氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成 |
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| 引用本文： | 史望宇,徐嘉擎,毛比明,贾皓,黄家兴,郭红超.氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成[J].有机化学,2020(3):756-762. |
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| 作者姓名： | 史望宇 徐嘉擎 毛比明 贾皓 黄家兴 郭红超 |
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| 作者单位： | 中国农业大学理学院化学系 |
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| 基金项目： | 国家自然科学基金(No.21572264)资助项目. |
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| 摘 要： | 采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的3+2]环加成反应,在温和条件下,以高产率(78%~94%)和高非对映选择性(>20∶1dr)构建了一系列具有螺环结构的吡唑类化合物.
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| 关 键 词： | 环加成 氰基亚胺 螺环化合物 吡唑 |
[3+2]Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines:Synthesis of Sipropyrazole Compounds |
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| Shi Wangyu,Xu Jiaqing,Mao Biming,Jia Hao,Huang Jiaxing,Guo Hongchao.[3+2]Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines:Synthesis of Sipropyrazole Compounds[J].Chinese Journal of Organic Chemistry,2020(3):756-762. |
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| Authors: | Shi Wangyu Xu Jiaqing Mao Biming Jia Hao Huang Jiaxing Guo Hongchao |
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| Institution: | (Department of Chemistry,College of Science China Agricultural University Beijing 100193) |
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| Abstract: | The3+2]cycloaddition of methylenedihydrobenzofbrandiones and nitrilimines worked efficiently in CHC13 at room temperature in the presence of Et3N,producing biologically interesting spirocyclic pyrazole derivatives in high yield(78%?94%)with excellent diastereoselectivity. |
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| Keywords: | cycloaddition nitrilimine spirocyclic compound pyrazole |
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