| 深共融溶剂中合成2,4-二取代喹啉衍生物 |
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| 引用本文： | 陈国庆,谢宗波,刘一帅,孟佳,乐长高.深共融溶剂中合成2,4-二取代喹啉衍生物[J].有机化学,2020(1):156-161. |
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| 作者姓名： | 陈国庆 谢宗波 刘一帅 孟佳 乐长高 |
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| 作者单位： | 东华理工大学核资源与环境国家重点实验室;东华理工大学应用化学系 |
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| 基金项目： | 国家自然科学基金(Nos.21462001,11765002);江西省科技计划(Nos.20161BCB24006,20181BAB203019)资助项目。 |
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| 摘 要： | 在氯化胆碱和氯化锌组成的深共融溶剂中,以2-氨基苯乙酮和芳香炔烃为原料,通过环化偶联反应,合成了一系列2,4-二取代喹啉衍生物;当n(氯化胆碱)∶n(氯化锌)=1∶2,反应温度为80℃时,反应3 h即获得高达98%的产率.该方法无需额外添加催化剂,而且反应条件温和、操作简单、底物范围较广泛.
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| 关 键 词： | 深共融溶剂 氯化胆碱 氯化锌 环化偶联 2 4-二取代喹啉 |
Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents |
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| Chen Guoqing,Xie Zongbo,Liu Yishuai,Meng Jia,Le Zhanggao.Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents[J].Chinese Journal of Organic Chemistry,2020(1):156-161. |
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| Authors: | Chen Guoqing Xie Zongbo Liu Yishuai Meng Jia Le Zhanggao |
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| Institution: | (State Key Laboratory,of Nuclear Resources and Environment,East China University of Technology,Nanchang 330013;Department of Applied Chemistry,East China University of Technology,Nanchang 330013) |
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| Abstract: | In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1∶2, the yield up to 98% was achieved at 80 ℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates. |
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| Keywords: | deep eutectic solvent choline chloride zinc chloride cyclization coupling 2 4-disubstituted quinoline |
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