D-呋喃核糖长链酰基衍生物的合成及生物活性研究

以N,N-二环己基碳二亚胺(DCC)作缩水剂, 使D-氨甲基呋喃核糖、苯甲酰氨基甲基呋喃核糖与长链脂肪酸发生缩合, 得到8个新型D-呋喃核糖的长链酰基衍生物, 通过波谱分析对其结构进行了确证. 并用噻唑蓝(MTT)法考察了所合成化合物对小鼠T-淋巴细胞增殖反应的影响. 结果显示: 长链酰基取代后的化合物4a～4d和5a～5d对小鼠T-淋巴细胞增殖的抑制活性明显优于未取代的底物2和3.

Synthesis and Biological Activity Study of Higher Fatty Acyl Derivatives of D-Ribofuranose

Using N,N-dicyclohexylcarbodiimide (DCC) as dehydration reagent, eight new higher fatty acyl derivatives of D-ribofuranose were obtained by the reaction of 3-aminomethyl-α-D-ribofuranose or 3-benzamidomethyl-α-D-ribofuranose with higher fatty acids. The structures of all the new compounds were confirmed by spectral analysis. And the effect of the synthesized compounds to T-lymphocyte transformation was investigated using methyl thiazolyl tetrazolium (MTT) method. The result showed that the inhibitory bioactivities of the syn-thesized compounds with higher fatty acyl 4a～4d and 5a～5d to T-lymphocyte were higher than those of the compounds without higher fatty acyl 2 and 3.