| N-取代乙醇胺对4-氟-1-酰基苯的选择性胺化反应 |
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| 引用本文： | 戴春亚,蔡良珍,赵韧,陶晓春.N-取代乙醇胺对4-氟-1-酰基苯的选择性胺化反应[J].有机化学,2007,27(1):116-119. |
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| 作者姓名： | 戴春亚 蔡良珍 赵韧 陶晓春 |
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| 作者单位： | 华东理工大学应用化学研究所,上海,200237 |
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| 摘 要： | 研究了4-氟-1-酰基苯和N-取代乙醇胺在酰胺类溶剂或不加溶剂中反应, 在不需要金属催化剂和另外加碱的条件下选择性地得到胺化产物, 实验操作简单, 符合SNAr取代机理. 一系列羟乙基胺基酰基苯产物均经过元素分析(HRMS), IR, MS和NMR的测定.
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| 关 键 词： | 4-氟-1-酰基苯 N-取代乙醇胺 胺化反应 |
| 收稿时间： | 2006-4-26 |
| 修稿时间： | 2006-04-26 |
Selective Amination of 4-Fluoro-1-acylbenzenes UsingN-Substituted Ethanolamine |
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| DAI,Chun-Ya,CAI,Liang-Zhen,ZHAO,Ren,TAO,Xiao-Chun.Selective Amination of 4-Fluoro-1-acylbenzenes UsingN-Substituted Ethanolamine[J].Chinese Journal of Organic Chemistry,2007,27(1):116-119. |
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| Authors: | DAI Chun-Ya CAI Liang-Zhen ZHAO Ren TAO Xiao-Chun |
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| Institution: | Institute of Applied Chemistry, East China University of Science and Technology, Shanghai 200237 |
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| Abstract: | A selective and simple amination of 4-fluoro-1-acylbenzenes was achieved by using N-substituted ethanolamine neatly or in amidated solvent. The procedure in the absence of metal catalysts and additional bases was carried out throughout SNAr substitution mechanism. A series of 4-N-alkyl-N- (2-hydroxylethyl)]amino-1-acylbenzene products were characterized by elemental analysis (HRMS), IR, MS and NMR spectra. |
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| Keywords: | 4-fluoro-1-acylbenzene N-substituted ethanolamine amination |
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