| 无溶剂条件下合成顺/反3-芳基亚甲基-2,3-二氢-吲哚-2-酮类化合物 |
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| 引用本文： | 徐天图,汪顺义,纪顺俊.无溶剂条件下合成顺/反3-芳基亚甲基-2,3-二氢-吲哚-2-酮类化合物[J].有机化学,2006,26(10):1414-1417. |
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| 作者姓名： | 徐天图 汪顺义 纪顺俊 |
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| 作者单位： | 苏州大学化学化工学院,江苏省有机合成重点实验室,苏州,215123 |
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| 基金项目： | 国家自然科学基金(Nos.20172039,20472062)，江苏省研究生创新计划资助项目. |
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| 摘 要： | 无溶剂条件下, 芳香醛与2-吲哚酮在碱性条件下通过研磨, 方便有效地合成了一系列3-芳基亚甲基-2,3-二氢- 吲哚-2-酮类化合物, 该反应条件温和, 时间短, 产率高, 对环境友好. 产物的结构得到1H NMR, IR, HRMS的表征, 其中(Z)-3e和(Z)-3j的结构得到了X单晶衍射的进一步确证.
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| 关 键 词： | 无溶剂 3-芳基亚甲基-2 3-二氢-吲哚-2-酮类化合物 吲哚酮 Knoevenagel缩合 |
| 收稿时间： | 11 16 2005 12:00AM |
| 修稿时间： | 04 6 2006 12:00AM |
Facile Synthesis of Z/E-3-Arylmethylidene-2,3-dihydroindol-2-one under Solvent-Free Conditions |
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| XU, Tian-Tu,WANG, Shun-Yi,JI, Shun-Jun.Facile Synthesis of Z/E-3-Arylmethylidene-2,3-dihydroindol-2-one under Solvent-Free Conditions[J].Chinese Journal of Organic Chemistry,2006,26(10):1414-1417. |
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| Authors: | XU Tian-Tu WANG Shun-Yi JI Shun-Jun |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123 |
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| Abstract: | A series of 3-arylmethylidene-2,3-dihydroindol-2-one derivatives 3 were conveniently synthe-sized by the condensation of aromatic aldehydes with 2-dihydroindol-2-one under basic and solvent-free conditions by grinding. All the products were determined by 1H NMR, IR, and HRMS spectra, with the con-figurations of (Z)-3e and (Z)-3j confirmed by X-ray analysis. |
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| Keywords: | solvent-free 3-arylmethylidene-2 3-dihydroindol-2-one 2-oxoindole knoevenagel condensa-tion |
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