取代嘧啶化合物的合成和生物活性研究

合成了14个新型取代嘧啶类化合物,结构经质谱、红外光谱、氢核磁共振光谱和元素分析确证.杀虫、杀菌和除草活性测定结果表明,部分化合物具有良好的杀菌活性.在嘧啶环的2-位上导入二甲氨基时表现出杀菌活性,但在嘧啶环的5-位上有甲基取代基时,杀菌活性下降.在嘧啶的4-位导入苯氧基时,显示出良好的杀菌活性,如化合物3b,3c和3e,苯环上的最优取代基是2-硝基-4-三氟甲基.

Synthesis and Biological Activity of Substituted Pyrimidine Derivatives

Fourteen new substituted pyrimidines were synthesized and their structures were confirmed by 1H NMR, IR, MS spectra and elemental analyses. Their insecticidal, fungicidal and herbicidal activities were examined. Some of these compounds showed good fungicidal activity after introduction of dimethylamino into the 2-position of pyrimidine ring. The compound with the phenoxy substructure at the 4-position of pyrimidine ring also showed good fungicidal activity, e.g. 3b, 3c and 3e. But compounds with methyl at the 5-position on the pyrimidine ring diminished the fungicidal activity. The best substituent on phenyl ring was 2-nitro-4-trifluoromethyl.