| 四氢异喹啉衍生物的合成研究 |
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| 引用本文： | 冯志强,杨晓莉,叶原丰,郝凌云,胡金刚.四氢异喹啉衍生物的合成研究[J].有机化学,2011,31(7). |
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| 作者姓名： | 冯志强 杨晓莉 叶原丰 郝凌云 胡金刚 |
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| 作者单位： | 1. 金陵科技学院材料工程学院 南京 211169
2. 东南大学化学化工学院 南京 211189 |
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| 基金项目： | 江苏省教育厅高校自然科学研究，金陵科技学院校级课题 |
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| 摘 要： | 以间甲氧基苯乙胺和氯甲酸乙酯为原料,通过亲核取代、关环、铝锂氢还原、脱甲基以及在N位上Boc保护及脱保护等9步反应得到一系列重要的1,2,3,4-四氢异喹啉及其衍生物.产物的结构经核磁共振氢谱、红外光谱及元素分析确证.与传统四氢异喹啉衍生物的合成工艺相比,该工艺反应条件温和、简便、经济、产率高且对环境友好.
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| 关 键 词： | 间甲氧基苯乙胺 1 2 3 4-四氢异喹啉 关环 |
Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives |
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| Feng Zhiqiang,Yang Xiaoli,Ye Yuanfeng,Hao Lingyun,Hu Jingang.Synthesis of 1,2,3,4-Tetrahydroisoquinoline Derivatives[J].Chinese Journal of Organic Chemistry,2011,31(7). |
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| Authors: | Feng Zhiqiang Yang Xiaoli Ye Yuanfeng Hao Lingyun Hu Jingang |
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| Institution: | Feng,Zhiqiang,a Yang,Xiaolia Ye,Yuanfenga Hao,Lingyuna Hu,Jingangb(a School of Material Engineering,Jinling Institute of Technology,Nanjing 211169)(b School of Chemistry & Chemical Engineering,Southeast University,Nanjing 211189) |
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| Abstract: | A series of important 1,2,3,4-tetrahydroisoquinoline derivatives were synthesized from 2-(3-methoxyphenyl)ethylamine and ethyl chloroformate by nucleophilic substitution,cyclization,LiAlH4 reduction and other reactions amounting to 9 steps.The structures of the products were characterized by IR,1H NMR spectra and elemental analysis.Compared to the traditional synthetic procedures of tetrahydro-isoquinoline,our procedures were temperate,convenient,economical,high-yielding and environment-friendly. |
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| Keywords: | 2-(3-methoxyphenyl)ethylamine 1 2 3 4-tetrahydroisoquinoline cyclization |
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