2-取代-3-芳基-4-噻唑啉(硫)酮衍生物的合成、晶体结构和生物活性

从2-取代-3-芳基-4-噻唑啉酮(4a～4e和5)合成了三个系列新型噻唑啉酮衍生物, 即5-芳基亚甲基-4-噻唑啉酮(6a～6j), 4-噻唑硫酮(7a～7e和8)和4-氰基亚胺基噻唑烷(11a～11e和12). 中间体4a～4e和5由醛、胺和巯基乙酸缩合得到. 所有化合物的结构均经元素分析和¹H NMR确证, 并且采用X射线单晶衍射分析方法测定了化合物4b的结构. 初步生物活性试验结果表明, 部分标题化合物具有一定的杀菌活性和促进黄瓜子叶生根活性.

Synthesis, Crystal Structure and Biological Activities of 2-Substituted- 3-aryl-4-thiazolidinone(thiazolidinethione) Derivatives

Three series of new thiazolidinone derivatives, namely 5-arylidene-4-thiazolidinones (6a-6j), 4-thiazolidinethione (7a-7e and 8) and 4-cyanoiminothiazolidine (lla-lle and 12) were synthesized from 2-substituted-3-aryl-4-thiazolidinones (4a-4e and 5). The intermediates 4a-4e and 5 were synthesized by the condensation of aldehyde, amine and mercapto acetic acid. Their structures were characterized by elemental analysis and 1H NMR spectra, and the structure of 4b was determined by X-ray single crystal diffraction method. The preliminary bioassay showed that some title compounds exhibited certain fungicidal activities and promoting cucumber cotyledon root-formation activities.