| 新型1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物的合成及其抑菌活性研究 |
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| 引用本文： | 李少博,胡德禹,宋宝安,杨松,金林红,薛伟,曾松,王俊,陈卓,卢平,周霞,樊玲娥.新型1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物的合成及其抑菌活性研究[J].有机化学,2008,28(2):311-316. |
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| 作者姓名： | 李少博 胡德禹 宋宝安 杨松 金林红 薛伟 曾松 王俊 陈卓 卢平 周霞 樊玲娥 |
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| 作者单位： | 贵州大学精细化工研究开发中心,教育部绿色农药与农业生物工程重点实验室,贵阳,550025 |
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| 基金项目： | 科技部国际合作项目，国家自然科学基金，贵州省省长基金 |
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| 摘 要： | 以1,5-二苯基-1,4-戊二烯-3-酮肟和酰氯为原料, 合成了15个新型的1,5-二苯基-1,4-戊二烯-3-酮肟酯类化合物, 通过元素分析, IR, 1H NMR, 13C NMR等对其结构进行了表征. 初步生物活性试验结果表明, 在50 mg•L－1浓度下, 化合物3i和3o对小麦赤霉病菌抑制率分别为51.1%和 53.4%, 与对照药剂恶霉灵抑制活性相当.
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| 关 键 词： | 戊二烯酮 肟酯 合成 抑菌活性 |
| 收稿时间： | 2007-02-10 |
| 修稿时间： | 2007-09-01 |
Synthesis and Antifungal Activity of Novel 1,5-Diphenyl- 1,4-pentadien-3-one Oxime Esters |
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| LI Shao-Bo,HU De-Yu,SONG Bao-An,YANG Song,JIN Lin-Hong,XUE Wei,ZENG Song,WANG Jun,CHEN Zhuo,LU Ping,ZHOU Xia,FAN Ling-E.Synthesis and Antifungal Activity of Novel 1,5-Diphenyl- 1,4-pentadien-3-one Oxime Esters[J].Chinese Journal of Organic Chemistry,2008,28(2):311-316. |
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| Authors: | LI Shao-Bo HU De-Yu SONG Bao-An YANG Song JIN Lin-Hong XUE Wei ZENG Song WANG Jun CHEN Zhuo LU Ping ZHOU Xia FAN Ling-E |
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| Institution: | (Key Laboratory of Green Pesticide and Agricutural Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025) |
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| Abstract: | Fifteen 1,5-diphenyl-1,4-pentadien-3-one oxime esters were synthesized by the reaction of 1,5-diphenyl-1,4-pentadien-3-one oxmie with acyl chloride. Their structures were identified by elemental analysis, IR, 1H NMR and 13C NMR spectra. The preliminary bioassay showed that compounds 3i and 3o had certain antifungal activities against Fusarium graminearum with rate of 51.1% and 53.45% at a concentration of 50 mg•L－1 respectively, similarly to the control (hymexozole). |
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| Keywords: | pentadienone oxime ester synthesis antifungal activity |
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