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| 无配体、在空气下Pd(OAc)2催化的Heck反应研究 | |
| 引用本文： | 陈为,于淼,焦宁.无配体、在空气下Pd(OAc)2催化的Heck反应研究[J].有机化学,2010,30(3):469-473. |
| 作者姓名： | 陈为 于淼 焦宁 |
| 作者单位： | (中国人民解放军军医进修学院 北京 100853) (中国人民解放军总医院放射诊断科 北京 100853) (北京大学药学院 天然药物及仿生药物国家重点实验室 北京 100191) |
| 摘 要： | 研究了无配体、空气下Pd(OAc)2催化的Heck反应. 多种芳基碘化物、芳基溴化物可以与烯丙基醋酸酯、丙烯酸酯和苯乙烯等烯基化合物在Pd(OAc)2催化下发生Heck反应. 该反应不需要配体的加入, 在空气中就可以进行. 讨论了碱、添加剂、溶剂、催化剂等因素对反应产率的影响. 该反应的最优化条件是: Pd(OAc)2 (5 mol%)为催化剂, Ag2CO3 (0.6 equiv.)为添加剂, 以苯或甲苯为溶剂空气中回流12 h, 芳基碘化物、芳基溴化物可以顺利地与烯丙基醋酸酯、丙烯酸酯、苯乙烯等烯基化合物发生Heck反应, 以较高的产率得到目标产物. |
| 关 键 词： | 无配体 Pd催化 Heck反应 |
| 收稿时间： | 2010-01-16 |
| 修稿时间： | 2010-02-28 |
Ligand-Free Pd(OAc)2 Catalyzed Heck Reaction under Air |
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| Institution: | (Chinese PLA Postgraduate Medical School, Beijing 100853) (Department of Radiology, Chinese PLA General Hospital, Beijing 100853) (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191) |
| Abstract: | Ligand-free Pd(OAc)2 catalyzed Heck reaction under air was studied in this work. Iodobenzene, bromobenzene and their derivatives reacted smoothly with different alkenes in the presence of palladium acetate. The reactions were conducted under air in the absence of ligand. The effect of base, additives, solvents and catalysts on this transformation was investigated. The optimized reaction conditions were approved as: Pd(OAc)2 (5 mol%), Ag2CO3 (0.6 equiv.), reflux in benzene or toluene under air. |
| Keywords: | ligand-free Pd-catalyzed Heck reaction |
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