| 2-乙烯基噻吩-8-羟基喹啉锌的设计合成及光致发光特性研究 |
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| 引用本文： | 刘坚,曾和平,徐丹凤,魏杰平.2-乙烯基噻吩-8-羟基喹啉锌的设计合成及光致发光特性研究[J].有机化学,2008,28(4):644-648. |
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| 作者姓名： | 刘坚 曾和平 徐丹凤 魏杰平 |
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| 作者单位： | 1. 华南师范大学有机化学研究所,广州,510631
2. 华南师范大学有机化学研究所,广州,510631;华南理工大学化学科学学院功能分子研究所,广州,510641 |
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| 基金项目： | 国家自然科学基金，广东省科技攻关计划 |
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| 摘 要： | 合成了2-2-(5-溴代噻吩-2-基)-乙烯基]-8-羟基喹啉(1)和2-2-(5'-溴代二噻吩-5-基)-乙烯基]-8-羟基喹啉(2)两个新化合物; 利用IR, UV, 1H NMR, MS, 元素分析等确认其结构; 利用X射线单晶衍射仪测定了化合物1的晶体结构; 用MTT法评价了化合物1和2对鼠骨髓间质干细胞在不同浓度下的影响, 研究结果表明它们对鼠骨髓间质干细胞具有增殖作用. 化合物1和2与醋酸锌反应获得了其相应的锌配合物3和4, 光致发光显示: 它们的λmax分别是597和620 nm.
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| 关 键 词： | 2-乙烯基噻吩-8-羟基喹啉 光致发光 调控骨髓间质干细胞增殖作用 |
| 收稿时间： | 2007-4-25 |
| 修稿时间： | 2007年4月25日 |
Synthesis and Optical Properties of Zinc Complexes with 2-Thienylvinyl-8-hydroxyquinolines |
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| LIU Jian,ZENG He-Ping,XU Dan-Feng,WEI Jie-Ping.Synthesis and Optical Properties of Zinc Complexes with 2-Thienylvinyl-8-hydroxyquinolines[J].Chinese Journal of Organic Chemistry,2008,28(4):644-648. |
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| Authors: | LIU Jian ZENG He-Ping XU Dan-Feng WEI Jie-Ping |
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| Institution: | (Department of Chemistry, South China Normal University, Guangzhou 510631)( Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641) |
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| Abstract: | 2-2-(5-Bromo-thiophen-2-yl)-vinyl]-8-hydroxyquinoline (1) and 2-2-(5'-bromo-bithiophenyl- 5-yl)-vinyl]-8- hydroxyquinoline (2) were synthesized and characterized by IR, UV, 1H NMR, MS spectra and elemental analysis. The crystal structure of compound 1 was determined by X-ray single crystal diffraction. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSC) have been evaluated by an MTT assay. The result of experiment indicated that compounds 1 and 2 could induce the proliferation of mesenchy-mal stem cells (MSC). The compounds 1 and 2 reacted with a Zn(II) salt to afford the cor-responding Zn(II) complexes 3 and 4, and their photoluminescences were showed at λmax 597 and 620 nm respectively. |
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| Keywords: | 2-(2-α-thienylvinyl)-8-hydroxyquinoline photoluminescence regulation of the proliferation of rMSC |
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