| N-(6-色酮-3-基-亚甲氨基)-S-{[4-芳基-5-(吡啶-4-基)]-1,2,4-三唑-2-基}巯乙酰胺类化合物的合成 |
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| 引用本文： | 曹玲华,燕珂.N-(6-色酮-3-基-亚甲氨基)-S-{[4-芳基-5-(吡啶-4-基)]-1,2,4-三唑-2-基}巯乙酰胺类化合物的合成[J].有机化学,2007,26(2):255-260. |
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| 作者姓名： | 曹玲华 燕珂 |
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| 作者单位： | 1. 新疆大学化学化工学院,乌鲁木齐,830046;南开大学元素有机化学国家重点实验室,天津,300071
2. 新疆大学化学化工学院,乌鲁木齐,830046 |
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| 基金项目： | 国家自然科学基金(Nos.29962002,20462006)资助项目. |
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| 摘 要： | N-芳基-2-(吡啶-4-基)羰基]氨基硫脲1a～1e用NaOH溶液环合, 得到3-巯基-4-芳基-5-(吡啶-4-基)-1,2,4-三唑(2a～2e), 经酯化, 肼解, 得S-{4-芳基-5-(吡啶-4-基)]-1,2,4-三唑-3-基}巯乙酰肼(3a～3e), 再与3-甲酰基色酮(4a～4d)反应, 合成得到了一系列新化合物5a～5e, 6a～6e, 7a～7e, 8a～8e. 化合物的结构经元素分析, IR, 1H NMR和MS谱确证.
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| 关 键 词： | 3-甲酰基色酮 1 2 4-三唑 巯乙酰胺 |
| 收稿时间： | 2006-1-17 |
| 修稿时间： | 2006-01-17 |
Synthesis of N-(6-Chromon-3-ylmethyleneamino)-S-{[4-aryl-5-(pyrid-4-yl)]-1,2,4-triazol-2-yl}mercaptoacetamide |
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| CAO Ling-Hua,YAN Ke.Synthesis of N-(6-Chromon-3-ylmethyleneamino)-S-{[4-aryl-5-(pyrid-4-yl)]-1,2,4-triazol-2-yl}mercaptoacetamide[J].Chinese Journal of Organic Chemistry,2007,26(2):255-260. |
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| Authors: | CAO Ling-Hua YAN Ke |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Xinfiang University, Urumqi 830046;2. State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianfin 300071 |
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| Abstract: | A series of new compounds 5a～5e, 6a～6e, 7a～7e and 8a～8e were synthesized though condensation reaction of 3-formylchromones 4a～4d with S-{4-aryl-5-(pyrid-4-yl)]-1,2,4-triazol-3-yl}-
mercaptoacetylhydrazine (3a～3e) which were obtained by esterification and hydrazinoly-sis from 3-mercapto-4-aryl-5-(pyrid-4-yl)-1,2,4-triazoles (2a～2e) cyclized from N-aryl-2-(pyrid-4-yl)-carbonyl]
thiosemicarbazide (1a～1e) in NaOH solution. Their structures were established by ele-mental analysis, IR, 1H NMR and MS spectra. |
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| Keywords: | 3-formylchromone 1 2 4-triazole mercaptoacetamide |
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