Simultaneous determination of guanosine and guanosine-5'-triphosphate in biological sample using gold nanoparticles modified indium tin oxide electrode |
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Authors: | Goyal Rajendra N Oyama Munetaka Tyagi Anuradha |
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Institution: | a Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247 667, India b Division of Research Initiatives, International Innovation Center, Nishikyo-ku, Kyoto 615-8520, Japan |
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Abstract: | A nanogold modified indium tin oxide (ITO) electrode was used for the simultaneous determination of guanosine and GTP at pH 7.2. The electrode exhibited an effective catalytic response towards their oxidation and lowered the oxidation potential of guanosine by ∼120 mV and GTP by ∼183 mV. Linear concentration curves were obtained for guanosine with a detection limit of 9.8 × 10−8 M and 5.5 × 10−8 M for GTP. The concentration of guanosine and GTP were also estimated in the human blood plasma samples using gold nanoparticles modified ITO electrode with good reproducibility. |
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Keywords: | Nanogold modified indium tin oxide electrode Guanosine Guanosine-5&prime -triphosphate Differential pulse voltammetry Blood sample |
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