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Development and optimization of ultra-high performance supercritical fluid chromatography mass spectrometry method for high-throughput determination of tocopherols and tocotrienols in human serum |
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| Authors: | Veronika Pilařová Tomáš Gottvald Pavel Svoboda Ondřej Novák Karolína Benešová Sylvie Běláková Lucie Nováková |
| Institution: | 1. Department of Analytical Chemistry, Faculty of Pharmacy, Charles University in Prague, Heyrovského 1203, 500 05, Hradec Králové, Czech Republic;2. Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany CAS & Faculty of Science of Palacký University, Šlechtitel? 27, 783 71, Olomouc, Czech Republic;3. Research Institute of Brewing and Malting, Malting Institute Brno, Mostecká 7, 614 00, Brno, Czech Republic |
| Abstract: | The goal of this study was to develop an effective supercritical fluid chromatography method using single quadrupole MS for analysis of all isomeric forms of vitamin E. Finally, two fast and effective methods, the high resolution one and the high speed one, for the determination of 8 vitamin E isomers in human serum were developed. |
| Keywords: | Ultra-high performance supercritical fluid chromatography Mass spectrometry Liquid liquid extraction Tocopherols Tocotrienols Human serum |
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