Application of MoS2 modified screen-printed electrodes for highly sensitive detection of bovine serum albumin |
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| Authors: | Manil Kukkar Ashish Sharma Parveen Kumar Ki-Hyun Kim Akash Deep |
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| Institution: | 1. Central Scientific Instruments Organisation (CSIR-CSIO), Sector 30-C, Chandigarh, 160030, India;2. Academy of Scientific and Innovative Research, CSIR-CSIO, Sector 30-C, Chandigarh, 160030, India;3. UIET, Panjab University, Sector 14, Chandigarh, 160014, India;4. Department of Biotechnology, Kurukshetra University, Kurukshetra, 136119, India;5. Department of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, Republic of Korea |
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| Abstract: | The present work reports the application of a new molybdenum disulphide (MoS2)-based electrochemical platform for highly sensitive quantitation of an iron-binding protein, bovine serum albumin (BSA). The gold screen-printed electrodes were modified with MoS2 nanoflakes, followed by bioconjugation with anti-BSA antibodies. Using the above bioelectrode, cyclic voltammetric analysis was carried out in the presence of a Fe3+/Fe2+ redox probe which exhibited a linear response of peak current with varying concentrations of BSA up to 10 ng/mL (with a detection limit of 0.006 ng/mL). This study is novel in that it shows a considerable enhancement of signal during electrochemical sensing of a protein. |
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| Keywords: | MoS2 Immunosensing Bovine serum albumin Cyclic voltammetry |
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