Synthesis of molecular imprinted organic-inorganic hybrid polymer binding caffeine |
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| Authors: | Chin I Lin Abraham K Joseph Yu Chi Wang |
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| Institution: | a Department of Polymer Technology, Union Chemical Laboratories, Industrial Technology Research Institute, 321 Kuang Fu Road, Section 2, Hsinchu 300, Taiwan
b Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan |
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| Abstract: | Random copolymers of poly{(methacrylamide)-co-(vinyl trimethoxysilane)} and poly{(methacrylic acid)-co-(vinyl trimethoxysilane)} were synthesized via a free radical polymerization reaction. Acid catalyzed sol-gel process of tetraethylorthosilicate (TEOS) with aforementioned polymers in the presence of methyl xanthine class of alkaloid like caffeine resulted in the formation of highly transparent monoliths. Solvent extraction of the template leaves behind the recognition sites intact with high selectivity towards the print molecule. The ionic and non-specific adsorptions, which are considered to be the main disadvantages of the molecularly imprinted polymers (MIP), are prevented to a considerable extent by the end capping of surface silanol groups. The template binding efficiencies of MIP were determined by HPLC analysis. |
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| Keywords: | Inorganic-organic hybrid materials Sol-gel process Random copolymers MIP |
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