| 5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物的高效合成 |
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| 引用本文： | 许招会,林春花,廖维林.5-[(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物的高效合成[J].应用化学,2015,32(3):278-283. |
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| 作者姓名： | 许招会 林春花 廖维林 |
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| 作者单位： | 江西师范大学化学化工学院 南昌 330027 |
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| 基金项目： | 国家科技攻关计划(2001BA323C);江西省研究生创新基金(YC10A51)资助项目 |
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| 摘 要： | 在分子碘作用下,以吲哚、醛和2,2-二甲基-1,3-二噁烷-4,6-二酮为原料,通过三组分缩合反应合成了10种5-(3-吲哚基)-甲基]-2,2-二甲基-1,3-二噁烷-4,6-二酮衍生物。 当催化剂的用量为5%(摩尔分数)时,30 ℃反应60~90 min,收率为71.4%~97.3%。 此外,还探讨了分子碘的催化机理。
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| 关 键 词： | 二甲基二噁烷二酮 碘 醛 三组分反应 |
| 收稿时间： | 2014-06-05 |
Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives |
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| XU Zhaohui,LIN Chunhua,LIAO Weilin.Efficient One-Pot Synthesis of 5-[(Indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione Derivatives[J].Chinese Journal of Applied Chemistry,2015,32(3):278-283. |
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| Authors: | XU Zhaohui LIN Chunhua LIAO Weilin |
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| Institution: | Chemistry and Chemical Engineering Department,Jiangxi Normal University,Nanchang 330027,China |
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| Abstract: | Ten 5-(indol-3-yl)-methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized by the three component condensation reaction of indole, aldehyde and 2,2-dimethyl-1,3-dioxane-4,6-dione using iodine as the catalyst. The results indicates that the yields range from 71.4% to 97.3% at 30 ℃ for 60~90 min using 5% molar fraction of iodine. Furthermore, a mechanism for the reaction catalyzed by iodine is proposed. |
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| Keywords: | dimethyl-dioxane-dione iodine aldehydes three component condensation reaction |
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