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5-氟尿嘧啶修饰卟啉的合成及抗肿瘤活性
引用本文:任丽磊,彭晓霞,赵秀丽,祝红梅.5-氟尿嘧啶修饰卟啉的合成及抗肿瘤活性[J].应用化学,2016,33(12):1415-1419.
作者姓名:任丽磊  彭晓霞  赵秀丽  祝红梅
作者单位:廊坊师范学院化学与材料科学学院 河北 廊坊 065000
基金项目:河北省教育厅青年基金(QN2014117)和廊坊师范学院青年基金(LSZQ201204)资助项目
摘    要:合成了一种5-氟尿嘧啶修饰的自由卟啉(5-2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)卟啉)及其2种金属卟啉配合物:5-2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)锰卟啉和5-2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)锌卟啉。通过紫外可见光谱(UV-Vis)、红外光谱(IR)和核磁共振谱氢谱(1H NMR)对目标化合物进行了结构表征。用噻唑蓝法(MTT法)测定了自由卟啉、锰卟啉及锌卟啉分别对肺腺癌细胞株A549、肝癌细胞株Bel7402和人结肠癌细胞株HCT-8的抑制活性。其中,锰卟啉对人结肠癌细胞株HCT-8的半抑制浓度为IC50为17.8 mg/L,具有一定的细胞毒作用。

关 键 词:卟啉  氟尿嘧啶  抗肿瘤活性  
收稿时间:2016-02-01

Synthesis and Antitumor Activity of Porphyrin Modified with 5-Fluorouracil
REN Lilei,PENG Xiaoxia,ZHAO Xiuli,ZHU Hongmei.Synthesis and Antitumor Activity of Porphyrin Modified with 5-Fluorouracil[J].Chinese Journal of Applied Chemistry,2016,33(12):1415-1419.
Authors:REN Lilei  PENG Xiaoxia  ZHAO Xiuli  ZHU Hongmei
Institution:Faculty of Chemistry and Material Science,Langfang Teachers University,Hebei,Langfang 065000 ,China
Abstract:The porphyrin modified with 5-fluorouracil(5-2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) porphyrin) and its two metal porphyrin complexes: 5-2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) Mn porphyrin and 5-2-(5-fluorouracil-3-yl)-ethoxyphenyl]-10,15,20-tri(4-methoxyphenyl) Zn porphyrin were synthesized. The structures of the three compounds were characterized by ultraviolet visible spectroscopy(UV-Vis), infred spectroscopy(IR) and proton nuclear magnetic resonance spectroscopy(1 H NMR). The antitumor activities of these compounds to A549, Bel7402, HCT-8 were tested using the methyl thiazolyl tetrazolium(MTT) method. The results show that the IC50 value of Mn porphyrin to HCT-8 is 17.8 mg/L.
Keywords:porphyrin  fluorouracil  antitumor activity
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