| 环己基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性 |
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| 引用本文： | 林森,吴亚弟,邓瑞红,曹迁永.环己基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性[J].应用化学,2015,32(10):1114-1119. |
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| 作者姓名： | 林森 吴亚弟 邓瑞红 曹迁永 |
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| 作者单位： | 南昌大学化学系 南昌 330031 |
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| 基金项目： | 国家自然科学基金资助项目(21162017) |
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| 摘 要： | 采用环己基(三甲基硅基亚甲基)二氯化锡和芳香酸(物质的量比1:2)在三乙胺存在下,合成了8种新的混合二烃基锡化合物环己基(三甲基硅基亚甲基)锡二芳香酸酯。 通过IR、1H NMR、13C NMR和元素分析等技术手段对它们的结构进行了表征;部分化合物的生物活性测定初步结果表明,它们对肺腺癌细胞(A549)有较好的体外抗癌活性,抑制率均在75%以上。
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| 关 键 词： | 二烃基锡 合成 结构 抗癌活性 |
| 收稿时间： | 2015-02-06 |
Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates |
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| LIN Sen,WU Yadi,DENG Ruihong,CAO Qianyong.Synthesis,Structure and Antitumour Activity of Cyclohexyl((trimethylsilyl)methyl)stannanediyl Bisarylcarboxylates[J].Chinese Journal of Applied Chemistry,2015,32(10):1114-1119. |
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| Authors: | LIN Sen WU Yadi DENG Ruihong CAO Qianyong |
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| Institution: | Department of Chemistry,Nanchang University,Nanchang 330031,China |
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| Abstract: | Eight cyclohexyl((trimethylsilyl)methyl)stannanediyl bisarylcarboxylates were synthesized by the reaction of cyclohexyl(trimethylsilylmethyl)tin dichloride with arylcarboxylic acids. These compounds were characterized by IR, 1H NMR and 13C NMR spectra and elemental analysis. The preliminary bioassay tests of these compounds show good antitumour activities in vitro against tumour cells A549 and the inhibition rates are over 75%. |
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| Keywords: | diorganotin synthesis structure antitumour activity |
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