| 无溶剂氧化亚锡催化合成2-[(3-吲哚基)-甲基]丙二酸二甲酯衍生物 |
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| 引用本文： | 许招会.无溶剂氧化亚锡催化合成2-[(3-吲哚基)-甲基]丙二酸二甲酯衍生物[J].应用化学,2015,32(7):759-764. |
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| 作者姓名： | 许招会 |
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| 作者单位： | 江西师范大学化学化工学院 南昌 330027 |
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| 基金项目： | 国家科技攻关计划(2001BA323C);江西省研究生创新基金(YC10A51)资助项目 |
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| 摘 要： | 在氧化亚锡催化下,吲哚、醛和丙二酸二甲酯在无溶剂条件下三组分反应合成了10种2-(3-吲哚基)-甲基]丙二酸二甲酯衍生物。 反应无溶剂污染,反应条件温和,收率为58%~74%。 讨论了反应速度与取代基的关系,探讨了可能的缩合反应机理,并应用1H NMR、13C NMR、IR等技术手段确定了产品的结构。
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| 关 键 词： | (吲哚基)-甲基]丙二酸二甲酯 丙二酸二甲酯 硼酸 醛 无溶剂 |
| 收稿时间： | 2014-10-30 |
SnO Catalyzed Solvent-Free Synthesis of Dimethyl 2-[(Indol-3-yl)-methyl]malonate Derivatives |
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| XU Zhaohui.SnO Catalyzed Solvent-Free Synthesis of Dimethyl 2-[(Indol-3-yl)-methyl]malonate Derivatives[J].Chinese Journal of Applied Chemistry,2015,32(7):759-764. |
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| Authors: | XU Zhaohui |
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| Institution: | Chemistry and Chemical Engineering Department,Jiangxi Normal University,Nanchang 330027,China |
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| Abstract: | Ten dimethyl 2-(indol-3-yl)-methyl]malomate derivatives were synthesized by three-component one-pot reaction of indole with aldehydes and dimethyl malonate under solvent-free condition in the presence of SnO as the catalyst. The yields ranged from 58% to 74%. The advantages of this method are no solvent pollution and mild reaction conditions. Furthermore, a mechanism for this condensation reaction was proposed and the relationship between reaction rate and substituent groups was also studied. All the compounds synthesized were confirmed by 1H NMR, 13C NMR and IR. |
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| Keywords: | dimethyl [(indol-yl)-methyl]malonate dimethyl malonate SnO aldehydes solvent-free |
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