| 磷酸钾中和法邻甲酚羧化反应的绿色合成 |
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| 引用本文： | 伍琳娟,朱大建,肖瑟,雷以柱,郭园园,张盼盼,李光兴.磷酸钾中和法邻甲酚羧化反应的绿色合成[J].应用化学,2015,32(6):0-0. |
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| 作者姓名： | 伍琳娟 朱大建 肖瑟 雷以柱 郭园园 张盼盼 李光兴 |
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| 作者单位： | 华中科技大学化学与化工学院 武汉 430074 |
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| 基金项目： | 国家科技部863项目(NC2010 MA0137)资助 |
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| 摘 要： | 以邻甲酚和二氧化碳为原料,以磷酸钾为中和剂一步羧化合成邻甲基水杨酸及相关产物。探讨了反应条件对产率的影响。实验结果表明,当磷酸钾与邻甲酚物料比为2.5:1,反应温度150 ℃,反应压力3.0 MPa时,羧化反应产物总收率达到95.4%,同时邻甲基水杨酸收率也达到最大。与传统碳酸钾中和法相比,磷酸钾中和法产物在后处理过程中无二氧化碳放出,后处理过程中的磷酸根可制备为磷酸钾使用,新工艺是一条绿色化工路线。
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| 关 键 词： | 二氧化碳 磷酸钾 邻甲基水杨酸 绿色合成 邻甲酚 |
| 收稿时间： | 2014-10-09 |
Green Process for o-Cersol Carboxylation Using Potassium Phosphate Base |
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| WU Linjuan,ZHU Dajian,XIAO Se,LEI Yizhu,GUO Yuanyuan,ZHANG Panpan,LI Guangxing.Green Process for o-Cersol Carboxylation Using Potassium Phosphate Base[J].Chinese Journal of Applied Chemistry,2015,32(6):0-0. |
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| Authors: | WU Linjuan ZHU Dajian XIAO Se LEI Yizhu GUO Yuanyuan ZHANG Panpan LI Guangxing |
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| Institution: | School of Chemistry & Chemical Engineering,Huazhong University of Science & Technology,Wuhan 430074,China |
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| Abstract: | A green process of the carboxylation reaction of o-cresol with CO2 using K3PO4 as a base was studied for the synthesis of 2-hydroxy-3-methylbenzoic acid (o-MSA) and related carboxylated products. Various reaction parameters such as temperature, pressure, and the ratio of the base to substrate had been tested. The results show that 95.4% total yield of all carboxylated products in this Koble-Schmitt reaction is obtained using K3PO4 as a base under 3.0 MPa CO2 and 150 ℃. Additionally, no CO2 is released during the neutralization process following the Koble-Schmitt reaction and the K3PO4 can be recovered and recycled by neutralization of KH2PO4 with KOH. Therefore, this process allows a green fixation of CO2. |
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| Keywords: | carbon dioxide potassium phosphate hydroxy-methylbenzoic acid green synthesis o-cersol |
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