5-苄基-4-叔丁基-2-苄亚氨基噻唑的合成与杀菌活性

5-苄基-4-叔丁基-2-氨基噻唑与水杨醛衍生物反应制备了12种5-苄基-4-叔丁基-2-苄亚氨基噻唑类新化合物。初步测试了25种5-苄基-4-叔丁基-2-苄亚氨基噻唑的杀菌活性。结果表明,化合物1a(500mg/L)对水稻纹枯病菌抑制率为95%;化合物1i、1j、1l、1p、1q和1s(25mg/L)对小麦赤霉病菌的抑制率分别为55.1%、55.1%、51.3%、51.5%、51.5%和51.5%;化合物1i、1l和1s(25mg/L)对辣椒疫霉病菌抑制率分别为51.1%、51.9%和64.9%;化合物1h和1j(25mg/L)对黄瓜灰霉病菌抑制率为53.1%和61.2%;化合物1t、1o和1r(25mg/L)对油菜菌核病菌的抑制率分别为56.1%、56.1%和65.4%;化合物1w(25mg/L)对烟草赤星病菌的抑制率为52.6%。

Synthesis and Fungicidal Activities of 4-Tert-butyl-5-benzyl-2-benzyliminothiazoles

Twelve new 5-benzyl-4-tert-butyl-2-benzyliminothiazoles were synthesized via the reacitions of 5-benzyl-4-tert-butylthiazol-2-amines with salicyladehyde derivatives. The bioassay of twenty five 4-tert-butyl-5-benzyl-2- benzyliminothiazoles were made. The results of preliminary bioassay show that the inhibition rate of compound 1a(500 mg/L) is 95% against R.solani; the inhibition rates of compounds 1i, 1j, 1l, 1p, 1q and 1s(25 mg/L) are 55.1%, 55.1%, 51.3%, 51.5%, 51.5% and 51.5% against G.zeae respectively; the inhibition rates of compounds 1i, 1l and 1s are 51.1%, 51.9% and 64.9% against P.capsici; the inhibition rates of compounds 1h and 1j(25 mg/L) are 53.1% and 61.2% against B.cinerea respectively; the inhibition rates of compounds 1t, 1o and 1r(25 mg/L) are 56.1%, 56.1% and 65.4% against S.sclerotiorum respectively; and the inhibition rate of compound 1w(25 mg/L) is 52.6% against A.alternata.