实时直接分析电离质谱法快速检测化妆品中的3种成分

建立用于化妆品中违禁成分尿刊酸(URA)、准用防晒剂甲氧基肉桂酸乙基己酯(EHMC)、丁基甲氧基二苯甲酰基甲烷(B-MDM)快速检测的快速检测方法。 采用实时直接分析(DART)离子源结合四极杆飞行时间质谱(Q-TOF MS),在正离子模式下,采用Full scan扫描方式,将化妆品样品直接置于离子化区域内进行快速定性分析。 在定量分析时,采用筛网模块进样,对实验参数进行系统优化,测得3种成分的定量范围在25～1000 mg/L之间,线性关系良好(r＞0.99),该方法的最低检出限(S/N=3)为7.5 mg/L,最小定量限(S/N=10)为25 mg/L,方法回收率在96.7%～109.2%之间,精密度RSD(n=6)为3.59%～11.23%。 该方法操作简单、快捷高效、环保绿色,可广泛应用于化妆品中化妆品中违禁防晒剂及添加剂的快速筛查与定量检测。

Rapid Determination of Three Components in Cosmetics by Using Direct Real-time Analysis Ionization Mass Spectrometry

A rapid method for the determination of the contraindicated component urocanic acid(URA), approved sunscreens 2-ethylhexyl 4-methoxycinnamate(EHMC) and butyl-methoxydibenzoylmethane(B-MDM) in cosmetics were developed using direct analysis in real time (DART) of ion sources combined with four-pole flight mass spectroscopy. For qualitative analysis by positive ions, the Full MS/Targeted MS² mode is applied to obtain the mass spectrum and cosmetics can be directly analyzed in the ionized area. For quantitative analysis, DART parameters are systematically optimized to achieve the best detection performance and the module sampler is used for automatic sampling. The linear range of three kinds of components is 25~1000 mg/L in the calibration curve with a good linear relationship (r＞0.99). The lowest limit of detection (S/N=3) is 7.5 mg/L and the minimum quantitative limit (S/N=10) is 25 mg/L. The method recovery is 96.7%～109.2% and the precision RSD (n=6) is 3.59%～11.23%. The method is simple, rapid, efficient and environmentally-friend. It can be widely used in the rapid screening and quantitative detection of banned additives in cosmetics.