一类新型嘧啶苯氧(硫)醚的合成及生物活性

一类新型嘧啶苯氧(硫)醚的合成及生物活性;双乙烯酮; 氯硝基嘧啶; 苯氧（硫）醚; 嘧啶肼; 生物活性

Synthesis and Biological Activities of a Novel Series of 4-(Substituted-phenoxy or phenylthio)pyrimidines

The synthesis of 6-methyl-2-N,N-diethylaminopyrimidinol(2) from diethylgunidine nitrate(1) and diketene was studied.After nitration and then chlorization of 2,4-chloro-5-nitropyrimidine(4) was obtained,and a novel series of 5-nitro-4-(substituted-phenoxy or phenylthio)pyrimidines(5) were prepared via the(reaction) of 4 and substituted phenols or phenylthiols.Furthermore,a new reaction between the methyl mercaptoacetate derivative of 4(6) and hydrazine,which yields pyrimidinyl hydrazine(8) in which the thio-acetoacetic acid methyl ester behaves as a leaving group under the nucleophinlic attack.The structures of all of the compounds were confirmed by ~(1)H NMR,IR,MS,and elemental analysis.The preliminary bioassay indicated that some of the compounds showed moderate herbicidal,fungicidal and anti-TMV activities.